Tutorial Grand Rounds 2

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4 Terms

1
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Rhabdomyolysis

  • breakdown of skeletal muscle into myoglobin and creatine kinase

  • acute kidney injury


2
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simvastatin and clarithromyocin interaction

  • simvastatin is normally metabolized by liver enzyme CYP3A4

  • Clarithromycin is a strong CYP3A4 inhibitor


3
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how does hypericum extract reduce contraceptive efficacy

it induces CYP3A4 to increase metabolism of estrogen and progestin

4
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how does hypericum extract interact with SSRI’s

  • hypericum increases serotonergic activity

  • SSRI increase serotonin reuptake

  • can lead to serotonin syndrome