Plasma membrane and second messenger systems

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4 Terms

1
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What are the second messages systems in the endocrine system

Cyclic AMP and PIP2-Calcium

2
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What is cyclic AMP?

a secondary messenger that is formed by cytosolic ATP by adenylyl cyclase (from the plasma membrae)

3
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What is the cyclic AMP signaling mechanism

1) Hormone binds to receptor

2) G-Protein Activated

3) G Protein activates or inhibits effector enzyme adenylate cyclase

4) Adenylate Cyclase converts ATP to cAMP (a second messager)

5) cAMP activates protein kinase that adds phosphates to other proteins

4
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What is the PIP2-calcium signaling mechanism?

-hormone-activated G protein activates a phospholipase C

-activated phospholipase C splits PIP2 into two second messengers