THC Paper #3

Prenatal THC

Did not impair acquisition of learning tasks but caused impaired memory consolidation in offspring.

Acquisition vs. Consolidation

Acquisition refers to the initial learning of tasks, while consolidation is the process of stabilizing that information into memory.

Reversal Learning

A measure of cognitive flexibility that assesses the ability to adapt when task rules change.

Executive Function

Cognitive processes including working memory, flexible thinking, and self-control, noted as impaired in males exposed to prenatal THC.

Amphetamine Challenge

An assessment of dopaminergic function through locomotor activity, revealing dampened response in THC-exposed rats.

Sex Differences

Variability in cognitive task performance based on gender, with observed impairments in males for reversal learning.

Dopaminergic Maturation

The development of dopamine systems, which were shown to be altered by prenatal THC exposure, impacting responses to stimulants.

Endocannabinoid System

Involved in the regulation of synaptic plasticity and impacted by prenatal THC exposure through alteration of CB1 receptors.

Long-term Executive Dysfunction

Implications of prenatal THC exposure leading to sustained attentional deficits in adulthood.

Cognitive Domains

Areas of cognitive function, including basic learning, memory consolidation, and executive functions which are differentially affected by prenatal THC.