PHARM TEST 2 - CARDIO DRUGS TOPIC: EPI, NE, ISOPRO ETC PT 1

what happens when we give epi?

vasoconstriction to periphery and kidneys

vasodilation to vital organs

inc Hr

relaxation of gi smooth muscle

bronchodilation

inc BGL, inhibit insulin

inc coagulation

alpha 1 receptor

vasoconstriction

alpha 2 receptor

treatment of HTN , reduces the release of norepinephrine

beta 1 receptor

Increases heart rate and contractility.

beta 2 receptor

bronchodilation

epi routes

NOT PO! IV IM INHALED TOPIC SQ

concentration of epi dose w IV vs IM SQ

iv - 1 to 10,000

im/sq - 1 - 1,000

adverse effects of epi

inc bp = htn crisis

dysrhythmias

inc workload and o2 demands = angina

necrosis following extravasation

HYPERGLYCEMIA

norepi effects which receptors

a1,2

b1

chemical class of ne

cat

indications for ne

hypotensive states

cardiac arrest

ne differs from epi bc it does not

activate b2 receptors - does not promote hyperglycemia

ne cannot be given

PO (MAO AND COMT)

drug interactions with ne (same as epi)

mao inhibitors, tcas, general anesthetics, and adrenergic blocking agents

isoproteronol

bronchodilator (beta 2 agonist)

isoproterenol receptors

b1 and 2

isoproterenol indications

AV heart block, cardiac arrest, inc co during shock

isoproterenol adverse fx

tachydysrhythmias and angina

hyperglycemia in dm pts

drug interactions with isoproterenol

MAOIS, TCAS, BETA ADREN. BLOCKERS

routes for isoproternol

iv, im or intracardiac