E3 Structures and Enzymes

Cytosine

Thymine

Uracil

Adenine

Guanine

Carbamoyl-Phosphate

PRPP (Phosphoribosyl-Pyrophosphate)

PRPP-S (Phosphoribosyl-Pyrophosphate synthase)

CPSII (structure)

CPSII (Reaction)

Aspirate Trans-Carbomylase

Aspartate

N-Carbamoyl Asparate

Produced from Asparate and Carbamoyl-P by asparate transcarbamoylase in pyrimidine synthesis

Dihydroorotase (DHO)

L-Dihydroortate

Product produced from N-Carbamoyl Aspartate by Dihydroorotase

Dihydroxyoorotate Dehydrogenase

Orotate (Orodic Acid)*

Orotate phosphoribosyl-transferase

Orotidylate (OMP)

OMP-Decarobyxylase

Uridylate (UMP)

Uridine 5’-Tryphosphate (UTP)

Cytidylate synthetase (CTP-synthase)

Cytidine 5’-Tryphosphate (CTP)

dUMP

thymidylate synthase

dTMP

N5,N10-methylene-tetrahydrofolate

Serine hydroxymethyl transferase

tetrahydrofolate (THF)

dihydrofolate reductase

7,8-dihydrofolate

Glutamine-PRPP aminotransferase (purine synth step 1)

5-phosphoribosylamine

GAR synthetase (purine synth step 2)

GAR

IMP (inosine monophosphate)

IMP synthase (purine synth step 11)

AMP (adenylate)

XMP (xanthylate)

GMP (guanylate)

adenylosuccinate synthetase

adenylosuccinate

Product produced from IMP by adenylosuccinate synthetase whena ctivated by GTP.

adenylocussinate lyase

IMP dehydrogenase

GMP synthetase

Nucleoside monophosphate kinases

use ATP to form other nucleoside diphosphates

ATP + NMP ⇌ ADP + NDP

Nucleoside diphosphate kinases

convert nucleoside diphosphates to triphosphates

NTP_donor + NDP_acceptor ⇌ NDP_donor + NTP_acceptor

Ribonucleotide Reductase

5’Nucelotidase

Nucelosidase

Removes sugar

adenosine deaminase

guanine deaminase

xanthine oxidase (PURINE salvage)

Xanthene Oxidase (to URIC ACID)

Glutathione-B-Synthase

converts homocysteine to cysteine

Flurouracyl

5’-fluro-dUMP

Methionine adenosyltransferase

methyl transferase

Adenosine homocysteinase

Methionine synthase

Asparagine Synthetase

Creatine Kinase

Phenylalanine Hydroxylase

Glutathione ox

Glutathione red

N-Acetylglutamate (NAG)*

NAGS (N-acetylglutamate synthase)

Ariginase

Arginosuccinate Lyase

Arginosuccinate Synthetase

Ornithine Transcarbamylase (OTC)

Carbomyl-phosphate Sythase 1 (CPSI)

Glutamate Dehydrogenase

Glutaminase

Pyridoxal Phosphate (PLP)*

Alanine Aminotransferase (ALT)

Aspartate Aminotransferase (AST)

Pyruvate (PYR)

Oxaloacetate (OAA)

Alpha-Ketoglutarate (Alpha-KG)

HMG-CoA Reductase

HMG-CoA Synthase

Thiolase

Mevalonate

Activated Isoprene

Malonyl-CoA

Acetyl-CoA Carboxylase (ACC)

Citrate Lyase

MAT (transferase)

Involved in activation step of FA synthesis

B-Hydroxybutarate Dehydrogenase

B-Ketoacyl-CoA Transferase

Acetoacetate Decarboxylase

Acetyl-CoA Dehydrogenase

Enoyl-CoA Hydratase

B-Hydroxyacyl-CoA Dehydrogenase

Acetyl-CoA acetyltransferase (Thiolase)

CAT1 (CPT1)

CAT2 (CPT2)