B&B: Addiction

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8 Terms

1
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Nucleus Accumbens

  • Acts as the brain’s primary reward, motivations, and pleasure center.

  • Receives major dopaminergic input from the VTA through the mesolimbic pathway


2
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Stimulants

  • Cocaine and amphetamine are potent dopamine agonists

  • Cocaine deactivates the dopamine transporter proteins

  • Amphetamine stimulates the release of dopamine


3
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Cannabis

  • Stimulates the CB1 receptor

  • Causes memory impairment by disrupting the hippocampus


4
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Treatments for addiction

  • Methadone/Buprenorphin

  • Naltrexone

  • Disulfiram

  • Buproprion


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Methadone/Buprenorphin

  • Targets opiod receptors to reduce withdrawal symptoms, cravins and opioid use. Agonist


6
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Naltrexone

  • Opioid receptor antagonist used to treat alcohol and opioid use disorders.


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Disulfiram

  • Produces an aversive reaction when alcohol is consumed. Interferes with metabolites of alcohol breakdown in the liver.


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Bupropion

Dopamine/norepinephrine reuptake inhibitor used for smoking cessation.