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2 major dysfunctions in the process of cancer development
defective cell proliferation (growth)
defective cell differentiation
cancer development
can occur 2 ways, genetics or acquired during life
how can cancer be acquired during life
chemical, radiation, viral (hep or HIV)
process of cancer development
initiation (permanent DNA mutation)
promotion
progression
3 cancer classifications
anatomic site classification (tissue of origin)
histological grading (how abnormal)
clinical staging (speed of growth)
benign tumor classifications
• Local
• Cohesive
• Well-defined borders
• Pushes other tissue out of the way
• Slow growth
• Encapsulated
• Easily removed
• Does not reoccur
malignant tumor classifications
Invasive
Noncohesive
Does not stop at tissue border
Invades and destroys surrounding tissue
Rapid growth
Metastasizes to distant sites
Not always easy to remove
Can recur
7 warning signs of cancer
C - change in bowel/bladder habits
A - a sore that doesnt heal
U - unusual bleeding/discharge
T - thickening/difficulty swallowing
I - indigestion/difficult swallowing
O - obvious changes in wart/mole
N - nagging cough or hoarseness
4 cancer treatments
surgery
chemo
radiation
immunotherapy
4 cancer complications of treatment
nutrition
infection
emergent
pain
3 goals of cancer management
cure
control
palliation
primary factors that determine what therapy is used for cancer treatment
cell type
location and size
extent of disease
physiologic and psychologic status
expressed needs and desires
role of surgery in cancer treatment
prevention
determine diagnostic and treatment plan
cure and control
supportive care
rehabilitation
palliation of symptoms
diagnosis
chemotherapy
use of chemicals given as a systemic therapy for cancer and is usually for most solid tumors and hematologic cancers
chemotherapy can offer …
cure, control, or palliative care
cure and chemotherapy
mostly used for solid tumors and hematologic cancers
palliation and chemotherapy
relieve pain, relieve obstruction
prep and handling of chemotherapy agents
may pose occupational hazards
drugs may be absorbed through skin or inhalation
only properly trained personnel should handle drugs
how can chemotherapy be administered
oral
IM
peripheral IV
central venous access device
regional (Intraarterial, Intraperitoneal, Intrathecal/Intraventricular, Intravesical Bladder)
extravasation injury due to chemotherapy
happens when an intravenous (IV) fluid or medication accidentally leaks out of the vein and into the surrounding soft tissue
must watch for this
assess IV line patency and moniotor
if pt states hurts or burns, STOP
role of radiation therapy in cancer treatment
radiation is the emission of energy from a source and travels through space or some material
different types of ionizing radiation are used to treat cancer
technologic advances
radiation is used to treat a carefully …
defined area of the body
radiation therapy is not a … treatment for systemic disease
primary
radiation therapy may be used by itself or ..
with chemotherapy or surgery
9 nursing management/implications to watch for with chemo and radiation
bone marrow suppression
faitgue
GI disturbances
radiation skin reactions
chemo skin reactions
pulmonary effects
CV effects
cognitive effects
reproductive effects
manifestations of bone marrow suppression with chemo and radiation
infection, hemorrhaging, anemia
nursing implementation/management of bone marrow suppression with chemo and radiation
monitor temp, S/S of infection, CBC, avoid invasive procedures/punctures, give RBC growth factors
manifestations of fatigue with chemo and radiation
affects ADL
nursing implementations/management of fatigue with chemo and radiation
rest/work periods
manifestations of GI disturbances with chemo and radiation
N/V, diarrhea, anorexia, mucositis
nursing implementations/management of GI disturbances with chemo and radiation
antiemetics, low residue diet, electrolytes, small frequent meals, nutritional supplements, good oral hygiene
manifestations of radiation skin reactions with chemo and radiation
dry or wet of desquamation
nursing implementations/management of radiation skin reactions with chemo and radiation
avoid perfumes, skin irritants, use aloe, protect skin and keep clean
manifestations of chemo skin reactions with chemo and radiation
alopecia
nursing implementations/management of chemo skin reactions with chemo and radiation
support body image disturbances
manifestations of pulmonary effects with chemo and radiation
can cause irreversible and progressive lung disease
nursing implementations/management of pulmonary effects with chemo and radiation
depending upon effects to lungs
manifestations of CV effects with chemo and radiation
affects ADL/functioning of heart
nursing implementations/management of CV effects with chemo and radiation
baseline/follow up echocardiograms
manifestations of cognitive effects with chemo and radiation
chemo brain
nursing implementations/management of cognitive effects with chemo and radiation
patients can have thinking and memory problems
manifestations of reproductive effects with chemo and radiation
potential infertility and sexual dysfunction
nursing implementations/management of reproductive effects with chemo and radiation
prossible pre treatment spem and egg
immunotherapy
uses the immune system to fight cancer
some types called biologic therapy
boost or manipulate the immune system and create an environment not conducive for cancer cells to grow
attack cancer cells directly
immunotherapy side effects
Flulike symptoms
Fatigue, malaise, weakness
Anorexia/weight loss
Nausea/vomiting
Problems with CV system, neurological
Problems with renal and hepatic systems
nursing management with immunotherapy
Side effects occur more acutely and are dose limited
Can influence patient decision to continue therapy
May not be reported for fear treatment may be stopped
coping with immunotherapy
Assist in planning
Transportation, nutrition, emotional support
Teach symptom management to maintain quality of life
Offer community resources
patients with cancer may develop complications from …
continual growth of the malignancy into normal tissue
cachexia
malnutrition; fat and muscle depletion that needs nutritional counseling
primary cause of death with cancer
neutropenia
usual sites of infection with neutropenia
lungs
genitourinary tract system
mouth, rectum
peritoneal cavity
blood
oncologic emergencies of cancer complications
life threatening
occur as result of disease or treatment
emergencies can be obstructive, metabolic, or infiltrative
2 obstructive oncologic emergencies with cancer
superior vena cava syndrome
spinal cord compression
superior vena cava syndrome
obstruction by tumor or thrombosis
signs of superior vena cava syndrome
facial and periorbital edema
distention of veins of head, neck, and chest
seizures
headache
neurological symptoms
spinal cord compression
tumor in epidural space of spinal cord
signs of spinal cord compression
intense, localized, persistent back pain
motor weakness
sensory paresthesia and loss
change in bladder or bowel function
5 classifications of pain
acute
chronic
breakthrough
central
phantom
patient report of pain with cancer should always be believed and accepted as _______ _____ for pain assessment data
primary source
under treatment of cancer pain causes…
needless suffering
decreased quality of life
increased burden on family and caregivers
management of cancer pain
Fear of addiction is unwarranted
Numerous drug options for pain management
Nonpharmacologic interventions, including relaxation therapy and imagery, can be used effectively
psychologic support with cancer pain
Emphasis is placed on maintaining optimal quality of life
Positive attitude of patient, family, and health care providers can have a positive impact on the patient’s quality of life
May also influence prognosis
common fears of pt’s with cancer
Disfigurement, emaciation
Dependency
Disruption of relationships
Pain
Financial depletion
Abandonment
Death
late and long-term effects of cancer
secondary cancer
increased risk for comorbidities
psychosocial effects
healthy behaviors for cancer survivors
good nutrition
regular exercise
appropriate health screenings
culturally competent care for pts/families with cancer
Underserved populations are at risk for late-stage disease at time of diagnosis
You need to know how to
Assess for cultural differences
Identify barriers to care
Adapt care to meet specific cultural needs