microbio antibiotics

beta-lactams

Targets PBPs to prevent peptidoglycan cross linkages

vancomycin

targets D-Ala-D-Ala chain and prevents wall assembly

bacitracin

targets bactoprenol and inhibits cell wall synthesis

isoniazid

targets mycolic acids and prevents envelope synthesis

ethambutol

targets arabinogalactan and impairs wall assembly

streptomycin

inhibits 70S ribosome formation

gentamicin

binds to 30s ribosomal unit and causes misreading of mRNA

tetracycline

prevents tRNA binding at A site and stalls elongation

Chloramphenicol

binds to 50S portion and inhibits formation of peptide bond

Erythromycin

Macrolide; binds to 50S and stalls protein production

Oxazolidinones

binds to 50s to prevent 70s initiation complex formation

Mupirocin

Isoleucyl-tRNA synthetase, blocks tRNA charging

Amphotericin B

targets ergosterol, increases fungal membrane permeability

Fluconazole

targets ergosterol biosynthesis via lanosterol 14a-demythlase

Terbinafine

Allylamine; targets ergosterol biosynthesis via squalene epoxidase

Polymyxin

targets bacterial membrane lipids

Sulfonamides

targets folate synthesis pathway

Fluoroquinolones

targets DNA gyrase and topoisomerase and prevents resealing after cuts

viral nucleoside/nucleotide analogs

interferes with viral nucleic acid synthesis and prevents replication

Pleconaril

prevents attachment, uncoating, and genome release

Oseltamivir

inhibits NA enzyme responsible for virion release

HIV protease inhibitors

blocks cleavage of polyproteins and prevents mature virus

Formiversen

binds to viral mRNA and causes antisense translation