Italicized history of CPB

quiz study

1885

von Frey & Gruber construct the 1st pump

oxygenator

1915/1916

McLean discovers heparphosphatide (heparin)

1918

Howell and Holt name McLean’s discovery heparin

1937

Chargraff and Olson discover protamine-sulfate

1929

Forssmann (Germany) performs 1st heart

catheterization and angiogram

1934

Debakey develops first roller pump

1935

Carrel and Lindbergh devise the 1st blood pump (lindbergh gets credit for first)

1951 (April 5/6th)

Dennis performs the 1st total cardiopulmonary

bypass

1952 (July 3rd)

Dodrill performs the 1st successful left-heart bypass

1952 (September 2nd)

Lewis and Taufic use hypothermia and

occlusion to repair an ASD in a 5 year old

girl

May 6th, 1953

Gibbon performs the 1st successful use

of the heart-lung machine/pump oxygenator

1954 – 1955

Lillehei uses controlled cross-circulation successfully (Blood was drawn from the donor’s femoral artery – positive displacement pump – into the patient’s aorta; simultaneously, blood was drawn from the patient’s SVC – same pump – into the donor’s femoral vein)

May 13th, 1955

DeWall reports the 1st successful use of

the DeWall-Lillehei bubble oxygenator (first disposable oxygenator)

1956

Sones accidentally discovers direct coronary

angiography

1967

Barnard and Shumway perform the 1st orthotopic

heart transplant (ever)

1968

Rene Favaloro (Cleveland Clinic) and Dudley Johnson

(Milwaukee) reported vein repair of previously repaired

coronary arteries

1968 (1 person)

Dudley Johnson performed the 1st graft to the back of

the heart