Ribonucleotide Reductase & Deoxy-Nucleotide metabolism

AMP

GMP

UMP

CDP

rNDP

dNDP

role of RNR

removes 2’ OH group from ribose sugar to convert to deoxyribose sugar

role of NDK

converts from diphosphates to triphosphates

what binds to RNRs activity site

ATP and dATP

what activates RNRs activity site?

ATP

what deactivates RNRs activity site?

dATP

what binds to RNRs specificity site

ATP, dATP, dGTP, dTTP

what binds to RNRs catalytic site

ADP, CDP, UDP, GDP

What are the first diphosphates to be converted to dNDPs in RNR?

CDP and UDP

what triphosphate must bound to RNRs specificity site to allow GDP → dGDP

dTTP

what triphosphate must bind to RNRs specificity site to allow ADP → dADP

dGTP

what happens to RNR after it is inactivated by dATP?

structural change converts it to a octamer that no longer allows pathway for free radical