Other Pathogenic GNR - Pseudomonas, Francisella, Legionella, Coxiella

Pseudomonas aeruginosa

large GNR; not fastidious and grows on MacConkey agar; found in water, soil, and plants; oxidase positive, opportunistic

What are the populations most at risk from P. aeruginosa?

immunocompromised individuals, cystic fibrosis patients; and swimmers

What are the toxins produced by P. aeruginosa, and what disease does these bacteria cause?

lipid A endo toxin; causes fever, inflammation, and shock

Francisella tularensis

causes Tularemia/Rabbit Fever; acquired through ingestion; bug bites; aerosols; wounds; Biosafety III Lab

Legionella

spread by aerosolized contaminated water; requires L cysteine for growth, iron enhance growth, grows on BCYE or Chocolate agar

BCYE agar

Buffered Charcoal Yeast Extract media; yeast is rich in L cysteine and iron

What made the Legionnaires uniquely susceptible to this disease?

they were older, male, smokers, and immunocompromised

Coxiella burnetti

the most infectious disease in the world; most common endocarditis in Australia; causes Q fever, animals contract it through tick bites - humans inhale it; DOC is tetracycline

Bacteroides fragilis

most common bile resistant anaerobic gram negative rod isolated in peritonitis; normally found in colon

Prevotella species

Bile sensitive anaerobic gram negative rod; causes periodontal and pelvic infections; found in sinus, ear