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direct chemical/physical
drug react when combined, create perticipation, inactivation of active compounds
pharmakokinetic interaction
one drug alters other drugs ADME. system drug levels altered
pharmacodynamic interaction
drugs act on same pathway/receptor site which increases/decreases overall effect
combined toxicity
drugs with overlapping effects increase risk of harm
potentiative effect
drug intensifies action of other drug, enhanced theraputic outcome/increased risk of adverse toxic effects
inhibitory effect
drug decrease effect of other drug, can prevent theraputic goal from being reached
unique response
combininb drugs can produce effects that each drug individually cannot produce