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CN I
Olfactory
Type: Sensory
Assessment: Test patency of nostrils; present familiar, non-irritating smells to each nostril with eyes closed
Expected Findings: Bilateral identification of distinct smells
Abnormal Findings/Clinical Significance: Ansomia (loss of smell); indicates nasal obstruction, smoking, or olfactory tract trauma
CN II
Optic
Type: Sensory
Assessment: Snellen chart for distant visual acuity, Rosenbaum card for near vision; confrontation test of peripheral fields
Expected Findings: 20/20 vision; intact peripheral visual fields
Abnormal Findings/Clinical Significance: Deficits in visual acuity, filed cuts (hemianopia); indicates ON dysfunction, glaucoma, or stroke
CN III
Oculomotor
Type: Motor
Assessment: Assess pupillary response to light (direct/consensual) and accommodation; test extra-ocular movements (EOMs) via 6 cardinal fields of gaze
Expected Findings: Equal, round pupils reacting to light and accommodation (PERRLA); smooth conjugate eye movements
Abnormal Findings/Clinical Significance: Ptosis (drooping eyelid), dilated/non-reactive pupil strabismus; indicated CN III compression (aneurysm, increased ICP)
CN IV
Trochlear
Type: Motor
Assessment: Assess EOMs; ask patient to look downward and inward (towards nose)
Expected Findings: Smooth downward and inward eye movement without nystagmus
Abnormal Findings/Clinical Significance: Inability to turn eye downward/ward; vertical diplopia (double vision)
CN V
Trigeminal
Type: Both
Assessment: Motor - palpate temporal/masseter muscle while patient clenches teeth; Sensory - light touch with cotton wisp on ophthalmic (V1), maxillary (V2), and mandibular (V3) facial regions
Expected Findings: Equal masseter contraction strength; accurate, bilateral facial sensation detection
Abnormal Findings/Clinical Significance: Weakness in jaw clenching; absent facial sensation; absent corneal reflex - indicated brainstem or nerve pathology
CN VI
Abducens
Type: Motor
Assessment: Assess EOMs; ask patient to move eyes laterally toward temples
Expected Findings: Smooth lateral tracking of both eyes
Abnormal Findings/Clinical Significance: Strabismus; inability to abduct eye laterally (medical deviation)
CN VII
Facial
Type: Both
Assessment: Motor - request facial expressions (smile, frown, raise eyebrows, close eyes tightly against resistance, puff cheeks); Sensory - taste on anterior 2/3 of tongue (rarely tested routinely)
Expected Findings: Symmetric facial movements; equal strength, air retained in puffed cheeks
Abnormal Findings/Clinical Significance: Facial droop, asymmetry, flattening of nasolabial fold, inability to close eye (Bell’s Palsy vs. Stroke)
CN VIII
Vestibulocochlear
Type: Sensory
Assessment: Whispered voice test at 1-2 feet; Weber and Rinne tuning fork tests if hearing deficit noted
Expected Findings: Whispered words repeated correctly bilaterally; Air conduction > Bone Conduction
Abnormal Findings/Clinical Significance: Sensorineural or conductive hearing loss, vertigo, tinnitus, unsteady balance
CN IX
Glossopharyngeal
Type: Both
Assessment: Assess swallowing; observe symmetrical elevation of soft palate and uvula when patient says “Ah”; gag reflex (when indicated)
Expected Findings: Uvula rises midline; symmetrical soft palate elevation; intact gag reflex
Abnormal Findings/Clinical Significance: Asymmetric uvula deviation; dysphagia; increased risk of airway
CN XII
Hypoglossal
Type: Motor
Assessment: Inspect tongue in mouth; ask patient to protrude tongue; test lingual speech sounds (“light, tight, dynamite”)
Expected Findings: Tongue protrudes in midline without atrophy, tremors, or weakness
Abnormal Findings/Clinical Significance: Tongue deviates to affected side upon protrusion; dysarthia; indicates lower motor neuron lesion
PERRLA
Pupils Equal
Round
Reactive to Light (direct and consensual)
Accommodation
Direct Light Reflex
Constriction of pupil in eye directly exposed to light source
Consensual Light Reflex
Simultaneous constriction of contralateral pupil when light is shone in opposite
Pathophysiology - Light stimulus travels via CN II (afferent/sensory route) to brainstem, causing bilateral motor output via CN III (efferent route)
Anisocoria
Unequal pupil size
Expected - Normal variant present in ~5% of population if pupillary light reflexes are intact and bilateral equal baseline exists
Unexpected - New-onset unequal pupils; unilateral dilated non-reactive pupil indicates optic nerve damage, brain herniation, or acute CN III compression
Cortical Sensory Test
Stereognosis - Ability to recognize small, familiar object placed in hand with eyes closed
Loss = Tactile agnosia (parietal lobe lesion)
Graphethesia - Ability to read a number or letter traced on palm with eyes closed
Loss = Parietal lobe damage
Primary Sensory Tests
Light Touch - Soft touch using cotton wisp across distal dermatomes bilaterally
Pain Perception - Test discrimination between sharp and dull ends of a clean object
Vibration Sensation - Apply a vibrating 128 Hz tuning fork over bony prominences (great toe, malleolus, fingers); loss of vibration sense at ankle is an early sign of peripheral neuropathy (ex., diabetes mellitus, aging)
Monofilament Test (Diabetic Neuropathy Screening)
Press a 10g Semmes-Weinstein monofilament perpendicularly against 10 designated plantar sites until it bends slightly, holding for 1-2 seconds
Inability to perceive touch at 4 or more sites indicates loss of protective sensation, conferring high risk for foot ulceration
DTR Grade 0
Description: No response/Absent
Interpretation: Abnormal (lower motor neuron lesion, severe neuropathy)
Intervention: Assess motor strength; check thyroid function/metabolic state
DTR Grade 1+
Description: Sluggish, diminished, low normal
Interpretation: May be normal or indicate motor deficits
Intervention: Compare bilaterally; re-evaluate after reinforcement
DTR Grade 2+
Description: Expected/Active normal
Interpretation: Normal neurological finding
Intervention: Document baseline finding
DTR Grade 3+
Description: Slightly hyperactive, brisk
Interpretation: May be normal variant or mild upper motor neuron sign
Intervention: Assess for systemic signs of irritability (e.g., preeclampsia)
DTR Grade 4+
Description: Very brisk, hyperactive with clonus
Interpretation: Abnormal (upper motor neuron lesion, stroke, spinal cord injury)
Intervention: Assess of Clonus - rapidly dorsiflex foot and hold; observe for rhythmic involuntary muscular contractions; notify provider
Stroke Evaluation (FAST)
F - Face drooping: Ask patient to smile; look for unilateral facial droop or asymmetry
A - Arm weakness: Ask patient to extend both arms forward with palms up for 10 seconds; look for arm drift or weakness
S - Speech difficulty: Check for slurred speech dysarthria, or inappropriate word choice (“light, tight, dynamite”)
T - Time to call EMS/Emergency Escalation: Immediate notification of stroke team; note time last seen normal
Critical Neurological Red Flag Signs
Sudden Severe “Thunderclap” Headache: Max intensity reached within seconds (“worst headache of life”)
Pathophysiology: Subarachnoid hemorrhage
Acute Drop in Level of Consciousness (LOC): Sudden lethargy, obtundation, or stupor
Glasgow Coma Scale (GCS): Indicated severe brain injury or coma (C + V + M score)
Safety Rule: “GCS 8, Intubate!”; patient cannot maintain airway reflexes; prioritize immediate airway protection and notify emergency response team
Cerebellar Assessment
Gait: Observe normal walking across 10-20 ft
Expected: Smooth, rhythmic, effortless gait with reciprocal arm swing
Tandem Walking: Ask patient to walk straight line heel-to-toe
Expected: Ability to maintain balance & straight line
Romberg Test: Ask patient to stand with feet together, arms at side, and close eyes for 20 seconds
Expected (Negative Romberg): Minimal or no swaying
Abnormal (Positive Romberg): Loss of balance, stepping out of stance when eye are close
Pathophysiology: Sensory ataxia, vestibular loss, or posterior column disease; Prioritize fall precautions