Escherichia Coli Strains

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Escheria Coli are what type(s) of pathogens

Frank and opportunistic

Where can Escherichia Coli can be found in the body?

Intestinal tract

During food digestion, Escherichia Coli produces what vitamin in the large intestine?

Vitamin K

Which Escherichia Coli strain is most likely part of the normal flora in the human body?

Enteroaggregative E. coli

How can enteroaggregative E. coli cause diarrhea?

Adhering to the mucosal surface of the intestine

How can Enteroaggregative E. coli enter the urinary tract?

By wiping back to front

Enteroaggregative E. coli is the most common cause of what infection?

UTI and Kidney infections

What protein helps Enteroaggregative E. coli stick to the urinary tract epithelial mucosa?

Adhesion

What does Enteroaggregative E. coli produce to kill leukocytes and inhibit phagoctyosis?

Hemolysins

What are the two most common conditions Enteroaggregative E. coli can septicemia and meningitisitis?

Septicemia and meningitis

How can Enteroaggregative E. coli enter a neonate?

It moves through the birth canal, and the vaginal tract is colonized

How does Enteroaggregative E. coli enter the vaginal tract?

Pelvic floor stretches, thins, and through eventually tear during active labor

Enteroaggregative E. coli produces the capsular antigen…

K1

Antigen K1 can help Enteroaggregative E. coli adhere to the neonate’s

Tissues

In rare cases, Enteroaggregative E. coli may be found where in an adult?

Blood

When Enteroaggregative E. coli is found in the blood, it typically causes inflammation where in an adult?

Genitourinary tract

Enteropathogenic E. Coli is the most common cause of…

Childhood diarrhea

Enteropathogenic E. Coli cases are the most common where?

Preschools and daycares

What is Enteropathogenic E. Coli’s target host cell?

Cells of the small intestines

What will Enteropathogenic E. Coli do to the small intestine’s cells?

Destroy microvilli

True or false? Enteropathogenic E. Coli are invasive

False; they are invasive

True or false? Enteropathogenic E. Coli is self-limiting

True

Why is Enteropathogenic E. Coli the most common cause of childhood diarrhea?

Kids don’t have good hygiene

Enterotoxigenic E. coli is referred to as…

Traveller’s diarrhea

How can Enterotoxigenic E. coli infect someone?

Consuming water in an oversea country

Enterotoxigenic E. coli infections are common in countries with…

Warm climates

Infective dose

The number of microbes needed to be ingested before symptoms begin

What is considered to be the range of cells in an infective dose?

1 million and 10 billion

Why does it take so many Enterotoxigenic E. coli cells to colonize the stomach?

The stomach’s pH is acidic

Enterotoxigenic E. coli targets what cells?

Cells of the small intestine

How does Enterotoxigenic E. coli colonize the stomach?

Use their adhesion proteins to bind to specific receptors on the microvilli

Once Enterotoxigenic E. coli is established in the small intestine, what does it produce?

Two toxins

Enterotoxigenic E. coli produces two toxins. What are they?

Heat stable and heat liable toxins

The two toxins Enterotoxigenic E. coli can cause what kind of disease? It is a ______-___________ disease

self-limiting

Enterotoxigenic E. coli can cause a disease that produced…

• Watery diarrhea

• Nausea

• Abdominal cramps

• Sometimes a fever

Enteroinvasive E.Coli causes what disease?

Dysentery

Enterotoxigenic E. Coli is considered a ________ pathogen

Frank

Enterotoxigenic E. Coli targets and kills what cells?

Large intestine cells

During an Enterotoxigenic E. Coli infection, after diarrhea ends, what will happen next?

Period of scanty stool production with pus, mucus, and blood

Enterotoxigenic E. Coli causes

• Fever

• Severe abdominal cramps

• Malaise

• Watery Diarrhea

• Toxemia

Enterotoxigenic E. Coli can cause vomiting that lasts up to how many days?

1-5 days

Toxemia

Toxin present in the blood

Enterotoxigenic E. Coli’s can cause a disease that is _____-_________

self-limiting

E. Coli O157:H7 contains what antigen(s)?

An O, H, and K antigen

At least how many plasmids does an E. Coli O157:H7 have?

One

What antibiotic is E.Coli O157:H7 sensitive to?

None of these—it’s antibiotic resistant

E.Coli O157:H7 has an increased ability to attach to host cells because it has adhesion proteins on its…

Pili

E.Coli O157:H7 produces two toxins that act on what cells of the body?

Colon cells

E.Coli O157:H7 will inflame the colon, causing what system in the human body to act upon it?

Immune system

The immune system will try to flush out E.Coli O157:H7 by doing what?

Cramping

During the immune system’s response to E.Coli O157:H7, the immune system will ramp up its response and become overactive. What may happen to the colon?

It will begin to degrade and digest our colon

E.Coli O157:H7 is the only strain that causes…

Bloody Diarrhea

E.Coli O157:H7 produces a toxin also made by Shigella. What toxin is it?

Virotoxin 1

E.Coli O157:H7 can produce another toxin alongside Virotoxin 1. What is the name of this toxin?

Virotoxin 2

Which E.Coli O157:H7 toxin can be treated with the shigella antitoxin?

Virotoxin 1

A patient has contracted E.Coli O157:H7. After bloody diarrhea, what follows after?

Hemorrhagic diarrhea

A patient has contracted E.Coli O157:H7. After hemorrhagic diarrhea, what follows after?

Colitis (inflammation of the colon)