Endoplasmic Reticulum

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Last updated 1:07 AM on 9/9/26
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13 Terms

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Holdases

These bind unfolded proteins & prevent protein aggregation.

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ER

Proteins are glycosylated in the _______ while translation is still happening.

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GPI Anchors

These are glycolipids that attach some proteins to the plasma membrane.

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BiP

This binds to unfolded polypeptides as they cross the ER; mediates folding and assembly.

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Protein Disulfide Isomerase (PDI)

This is an enzyme that assists in the folding of proteins with disulfide bonds.

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Lectin Chaperone

This binds glycosylated sugars.

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Calnexin

This allows proteins to refold.

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  1. ATF6

  2. IRE1

  3. PERK


These are the 3 main unfolded protein sensors:

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Flipases

These move lipids from one leaflet to another.

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ABC Flipase

This moves lipids from the cytosolic to the inner side.

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P-Flipase

This moves lipids from the inner leaflet to the cytosolic side.

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Scramblases

This moves lipids between the 2 leaflets.

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Mucin

This is the main component of mucus.