3.5 Pharmaceutics Exam 2 - Rate Process Part 1

☆ - Dr Guo mentions "may ask this on exam"; ★ - Dr Guo says will be on exam/wants you to remember

What is chemical kinetics?

• the process and time dependence of chemical degradation

• the mathematical principles of degradation

• first order and zero order reactions

What does chemical kinetics do?

help pharmacist determine beyond use dates, maintain proper storage conditions, develop stable products

★ Zero Order

What is [D]?

drug concentration

What is k₀?

rate constant for a zero order reaction

What is [D]₀?

initial drug concentration

What is [D]_t?

drug concentration after specified time t

★ Zero Order — Half Life

★ First Order

★ First Order — Half Life

In a zero order reaction constant ______ of the drug is degraded per unit time

amount

In a first order reaction constant ______ of the drug is degraded per unit time

proportional

Zero Order Elimination/Degradation

• drug decreases linearly with time

• rate of elimination is constant (amount)

• no true t_1/2

First Order Elimination/Degradation

• drug decreases exponentially with time

• rate of elimination is proportional to drug

• t_1/2 is constant regardless of drug