Lipase Lec

What is the EC of Lipase?

3.1.1.3

What is the other name of Lipase?

Triacylglycerol Acylhydrolase

Function: hydrolyzes the ester linkages of fats to produce alcohols and fatty acids

Lipase

True or False:

Lipase is filtered in the glomerulus but reabsorbed by tubules

True. (because its a small enzyme)

At what ester linkage positions does lipase hydrolyze?

positions 1 and 3

Lipase is primarily found in the?

Pancreas

Lipase is also found in the?

liver

stomach

small intestine

white blood cells

fat cells

milk

Performs initial digestion of fats (<10% of fats) in the mouth

Lingual lipase

Lingual lipase is from the?

Lingual glands

Where does the digestion of fats occur?

Small intestine

Bile come first before Lipase

Breakdown of fat globules into small sizes

emulsification

emulsification is by the?

bile

Bile is made out of?

bile acids + lecithin

Once emulsified, lipase can digest all fats within? (minutes)

1 minute

Lipase is almost exclusive to the diagnosis of ?

acute pancreatitis

Lipase:

Rise: ?

Peak: ?

Persist for about ?

Rise: 4-8 hours after onset of an attack

Peak: 24 hours

Persist for about 8-14 days

If lipase has more than 14 days rise this suggests ?

poor prognosis or pancreatic cyst

Lipase is found also in other intra-abdominal conditions such as:

Duodenal ulcers

Perforated peptic ulcers

Intestinal obstruction

Acute cholecystitis

True or False:
Lipase is abnormal in conditions with salivary gland involvement.

False. (Normal in conditions with salivary gland involvement)

These inhibit/delay the action of serum lipase

Proteins

Heavy metals

Quinine

Phospholipids

Bile salts in low concentrations will?

‘enhances’ lipase activity (Because it emulsifies the fat prior)

Bile salts in high concentrations will?

displace lipase from the substrate. (Because bile will remain attached)

reverses the inhibition of bile salts

Colipase