Selective Norepinephrine and Serotonin Reuptake (SNRIs)
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6 Terms
SNRIs increase the level of
norepinephrine and serotonin by inhibiting their reabsorption into cells in the brain
Venlafaxine
Effexor
Ventilate the EFFects
first SNRI to be marketed
half life for immediate release formation in 5 hours
low sexual side
XR- longer half life- 11 hours
effective in geriatric and melancholic depression
Dulozetine
Cymbalta
Cymbol has a DUEL meaning
MDD and GAD
treats chronic pain
used to treat pain caused by nerve damage
max dose is 60 mg
do not take with MAOI or with thioridazine
Desyenlafaxine
Pristiq
FAX the PRIest
3rd SNRI approved by FDA
50 mg starting dose
half life 11 hours
50% excreted in the urine
not approve under 18
Levomilancipran
Fetzima
Fetch the Mil
once per day
half life 12 hours
60% excreted in urine
two fold greater potency for norepinephrine
Side effects associated with SSRIs and SNRIs
headache
nausea
sleeplessness or drowsiness
agitation
sexual problems