I i Blood Group System

What is the structure of the big I antigens?

BRANCHED chain structure

Where are big I antigens found?

ADULT RBCs

What is the structure of the little i antigens?

STRIGHT chain

Where are little i antigens found?

NEWBORN RBCs

What is the prevalence of I i antigens?

HIGH, they are found on the RBCs of many individuals

Which I i genotype is RARE in ADULTS?

i i genotype

How do the I i antigens react with enzymes such as Ficin and Papain?

ENHANCED by enzymes

What kind of antibodies are Anti-I and Anti-i ?

IgM antibodies

At what temperature do Anti-I and Anti-i antibodies react best at?

COLD or room temp

What can pathogenic Anti-I cause?

Cold Agglutinin Disease (CAD)

What is seen in Cold Agglutinin Disease (CAD)?

Anti-I with a BROAD THERMAL ACTIVITY

Reacts at warm and cold temps causes AUTOAGGLUTINATION, then hemolysis

What can ADULTS with i i genotype develop?

Alloanti-I

When is Alloanti-I developed?

In cases of adults with i i genotype

Which I i antibody is associated with INFECTIOUS MONONUCLEOSIS (Mono)

Anti-i

Which antibody will react with RBCs that have BOTH the I and H antigen?

Anti-IH

Which blood group does Anti-IH react strongest with?

O group

O blood has the most H on its surface (all H pretty much)