MHC heterozygosity: benefits & other

How can infectious disease affect MHC diversity?

Infectious disease may act as a selective pressure on the maintenance of MHC heterozygosity (variation of alleles) within an individual and in a population.

How does MHC heterozygosity benefit a population?

A diverse array of heterozygosity limits the presence of a susceptible MHC allele and confers genetic herd immunity.

What is the advantage of MHC heterozygosity during infection?

The advantage is that more peptides from the pathogen can be displayed, providing a higher potential for T cells to be activated during infection.

How is MHC heterozygosity selected for?

MHC heterozygosity is selected for through balancing selection because it is advantageous in the body’s defense against any given pathogen.