Insulin secretion

Ca++ binds to ______ which acts at the contact points between vesicle/cell membrane junction to put bending stress to allow snares to accomplish membrane fusion.

synaptotagmin

When secretory vesicles arrive at the cell cortex, a docking protein called ______ binds to them to prevent unregulated progress to the cell membrane.

Synapsin

depolarization induces L-type channels to increase the Islet beta cell cytoplasm concentration of ____ to increase.

Ca++

contact with the cell membrane is mediated by vesicle _________s that interact with target _________s.

snare

In response to L-type channel action ______ phosphorylates the docking protein at the cortex boundary to release secretory vesicles to progress to the cell membrane.

CaMKII

The motor protein that moves secretory vesicles through the cell cortex is _____.

myosin5a

What protein is orchestrating all of the multiple steps of progress of proinsulin/insulin from the Golgi to the cell membrane?

Rab37

The ____ contains a GAP that acts on Rab/GTP at the cell membrane to permit fusion and secretion.

HOPS

The cell cortex is largely made up of microfilaments composed of _____ protein.

actin