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Carboprost
Postpartum bleeding
2nd trimester abortions
ADR: bronchoconstriction, n/v/d, inc body temp
Can give IM b/c 15-methyl blocks oxidation
Misoprostol
NSAID-induced gastric ulcer prevention in high-risk patients
ADR: abortion
Prodrug; food/antacids dec absorption
Treprostinil
pulmonary arterial hypertension
ADR: hypotension, infusion site pain
Can give SC
Iloprost
Pulmonary arterial hypertension
ADR: hypotension
Used via inhalation
Prostin VR
ductus arteriosus dependent congenital heart defects
Caverject, Edex, Muse
Erectile dysfunction
Dinoprostone
Cervical ripening/labor induction
2nd trimester abortion, evacuation of uterus in fetal death
Epoprostenol
Scleroderma, primary pulmonary hypertension