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Vitamins
Organic substances required by animals in small amounts for normal metabolism. Obtainable from the diet or a precursor in the diet and are NOT synthesized within body tissues a a rate good for metabolism
Vitamin recognition
A recognition developed that the known nutrients would not support life ( CHO, fats , proteins) Lunin in 1881
McCollum called
The fat soluble factor was found in butter fat-soluble A , as opposed to water-soluble B for the factor concerned in beri-beri
Fat Soluble
A,D,E,K
Water Soluble
VIT . C , B COMPLEX
1897 Eijkman
Isolated the cause of polyneuritis in poultry and beri-beri in man as being cured with rice hulls
1912 Funk
coined term ‘‘vitamin’’ after the amine fraction of rice hulls which he had isolated which prevented polyneuritis in bird
1913 Osborne and mendel
isolated a fat soluble substance from cod liver known as oil known as Vitamin A
Provitamins
compounds that give rise to vitamins
Antivitamins
Compounds that inhibits vitamins in some manner.
Vitamin A
Active as an alcohol, aldehyde,acetetae, palmitate and acid
Vitamin A palmitate
most popular synthetic form
vitamin A occurs
In animals only
Precursors called
Carotenoids exist in plants
Functions of vitamin A
Visual purple cycle rhodopsin which is the process of sight as a result of photochemical process
Deficiency in vitamin A
Reduced appetite, night blindness, xerophthalmia, runny eyes of cattle and sheep, increased respiratory problems, vaginal reproductive tract problems
Hypervitaminosis A
Skin thickening, suppressed keratinization
interference with bone development, loss of chondroitin sulfate
prolonged prothrombin time K -cures
cerebrospinal fluid pressure hydrocephalus
lowered plasma cholesterol in chicks
resorption of fetus
decreased appetite
carotene conversion
in rarts sheep goats and pigs carotene are not absorbed into the bloodstream but is converted into Vitamin A in the intestinal wall ( white fat species)
Carotene conversion in cow and horses
have considerable carotene in plasma , thus only part of carotene in feed is converted to Vitamin A (produces yellow fat)
vitamin A storage
Main storehouse is liver from 70-90% vitamin A found there. Remainder is in soft tissue such as fat depots, kidneys, and adrenals other organs.
Vitamin A sources
Fish oils, egg yolk, liver, milk fat,
Vitamin A sources
Carotenes, green color or chlorophyll mask yellow of carotenes. High in green leafy plants , decreases due to storage
Effects of chemical changes of vitamin A
Esterification, dehydrogenation, hydrogenation, heat in absence of moisture 6