Ch 11

Blocking mTOR activation prior to training would likely impair __________.

memory consolidation

mTOR is crucial for the initiation of local __________ synthesis, essential for the consolidation of long-term memory (LTM).

protein

Inhibiting mTOR prevents the translation of __________ needed to produce proteins that contribute to synaptic plasticity.

mRNAs

Rapamycin specifically inhibits __________, one of the two functionally distinct protein complexes formed by mTOR.

mTORC1

Administering an mTOR inhibitor prior to training is expected to prevent __________ and thus impair LTM.

memory consolidation

Administering the inhibitor a few minutes after training is predicted to have no effect on __________.

LTM

Neither pre- nor post-training administration of the mTOR inhibitor is expected to significantly impact __________.

STM

mTORC1 regulates the signaling cascade that increases local __________ synthesis.

protein

mTORC2 is insensitive to __________.

rapamycin

Actin dynamics are essential for the formation and maintenance of __________, the sites of synaptic plasticity.

dendritic spines

Guzowski used antisense oligodeoxynucleotides (ODNs) to disrupt CREB __________.

translation

Guzowski’s conclusion indicated that CREB is critical for __________ consolidation.

LTM

BDNF is considered a critical player in the phosphorylation of __________.

CREB

The activation of CREB by BDNF leads to the transcription of new __________ mRNA.

BDNF

This autoregulatory feedback loop sustains BDNF signaling, contributing to the long-term maintenance of __________ changes.

synaptic

The positive feedback loop involving BDNF and CREB exemplifies the interconnected nature of __________ mechanisms underlying memory.

molecular