Jones GI Final shi i forgot

Which transporter brings bilirubin into hepatocytes?

OATP

Which enzyme conjugates bilirubin, and where is it conjugated?

UGT1A1
Hepatocyte

What are the causes of unconjugated hyperbilirubinemia?

• Gilbert syndrome: impaired UGT1A1

• Crigler-Najjar: severe UGT1A1 mutation

• Lucey-Driscoll: reduced UGT1A1 activity

What are the causes of conjugated hyperbilirubinemia?

• Dubin-Johnson

• :Rotor:

Which transporter secretes bilirubin into bile duct?

MRP2

Which IBD has continuous inflammation of the colon?

UC

Which IBD can affect different intestinal regions with skip lesions?

Chrons

Which liver cells are involved in fibrosis?

Stellate

Which cells produce mucin in the intestine?

Goblet

Which cells produce antibacterial factors in intestinal crypts?

Paneth cells

Which cells capture and present antigens?

Dendritic cells

What are the three components of the hepatic portal triad?

hepatic artery, portal vein, and bile duct.