Glycoprotein/Proteoglycan

Hyaluronate

Glucuronic + N-Acetylglucosamide

Chondroitin sulfate

Glucuronic + N-Acetylgalactosamine sulfate

Heparan sulfate

Iduronic acid sulfate and glucuronic acid + Glucosamine bis-sulfate

Heparin 

Iduronic acid sulfate and glucuronic acid + Glucosamine bis-sulfate

Dermatan sulfate

Iduronic (some glucuronic) + N-Acetylgalactosamine sulfate

Keratan sulfate

Galactose + N-Acetylglucosamine

Location of Hyaluronate

Synovial fluid, vitreous humor, ECM of connective tissue, also found in neural tissues

Characteristics of Hyaluronate

Large polymers, lubricator and shock absorbing

Location of Chondroitin sulfate

Important structural component of cartilage, bone, heart valves. Treatment of osteoarthritis

Characteristics of Chondroitin sulfate

Most abundant GAG. Found as proteoglycans

Location of Heparan sulfate

Basement membranes, components of cell surfaces

Characteristics of Heparan sulfate

Contains higher acetylated glucosamine than Heparin. Blood anticoagulation. Found as proteoglycans.

Location of Heparin

Component of intracellular granules of mast cells lining the arteries of the lungs, liver and skin.

Characteristics of Heparin

More sulfated than Heparan sulfates. Blood anticoagulation. Found as proteoglycans.

Location of Dermatan sulfate

Skin, blood vessels, heart valves, tendons

Characteristics of Dermatan sulfate

Formerly called mucopolysaccharide. Found as proteoglycans.

Location of Keratan sulfate

Found in Bone, Cornea (I), and skeletal muscle (II). When in cartilage, aggregated with chondroitin sulfates

Characteristics of Keratan sulfate

Found as proteoglycans

Glycoproteins linkage Type I

N-Glycosyl linkage to Asn

Glycoproteins linkage Type II

O-Glycosyl linkage to Ser (Thr)

Glycoproteins linkage Type III

O-Glycosyl linkage to 5-HOLys

Glycoproteins linkage Type IV

O-Glycosyl linkage to Ser

Location of Glycoproteins linkage Type I

Plasma membrane proteins

Location of Glycoproteins linkage Type II

Plasma membrane proteins, Mucus secretions

Location of Glycoproteins linkage Type III

Collagen

Location of Glycoproteins linkage Type IV

Cytoplasmic proteins