Cm

Nucleus

Central organelle containing genetic material.

Perinuclear cage

Network surrounding the nucleus.

Centrosome

Microtubule organizing center.

Microtubules

Cytoskeletal elements providing structural support.

Leading process

Forward extension of the migrating neuron.

Dynein

Motor protein that moves toward the minus end of the microtubules.

Lis1

Regulator of dynein activity.

Myosin 2

Motor protein that squeezes actin at the rear of the nucleus.

NudE/Nudel

Proteins that cofactor with dynein to transport the nucleus forward.

Translocation of Organelles

The movement of organelles and nucleus during neuronal migration.

Mechanism of Centrosome Movement

Centrosome moves forward first, driven by dynein and Lis1 anchoring to plasma membrane.

Pushing force

Force generated by myosin 2 that squeezes actin at the rear of the nucleus.

Pulling force

Force exerted by dynein, Lis1, and NudE/Nudel to transport the nucleus forward.