selective estrogen receptor modulators (SERMS) raloxifene (EVISTA))

selective estrogen receptor modulators (SERMS) drug

Raloxifene (Evista)

Tamoxifen (Soltamox); Clompihene (Clomid); Ospemifene (Osphena); Tormifene (Fareston)

Indication of Raloxifene (Evista)

Prevention of invasive breast cancer in postmenopausal women at high risk,

prevention or treatment of osteoporosis in postmenopausal women

Mechanism of Raloxifene (Evista)

Acts as estrogen receptor agonist in bone to decrease bone resorption and increase bone mineral
density

Black Box Warnings of Raloxifene (Evista)

Venous thromboembolism and stroke

Contraindications of Raloxifene (Evista)

Pregnancy, lactation, past medical history of VTE or stroke

common adr of Raloxifene (Evista)

Hot flashes; Arthralgia (joint pain); Leg cramps; Peripheral edema

rare adr of Raloxifene (Evista)

Hypertriglyceridemia; Venous thromboembolism; Cerebrovascular accident (stroke); Pulmonary
embolism

Counseling points of Raloxifene (Evista)

Increases the risk of blood clots, especially during the first 4 months of therapy. Be aware of the
symptoms of DVT. Take once daily; with or without food