L17 - Eso + stomach high yield (cells/glands)

Stomach glands: function of cardiac glands?

Secrete mucus and lysozyme

Stomach glands: function of fundic glands?

Main acid (HCl) and enzymatic producing glands of the stomach

Stomach glands: Function of pyloric glands?

mucous production

function of Surface Epithelial (Mucous) cells of the stomach

Produces mucus to protect against acidic environment

function of Mucous Neck cells of the stomach

Produces mucus to maintain neutral pH at stomach surface

function of Undifferentiated/stem cells of the stomach

Mitotically active; replaces cells lost via apoptosis

function of parietal cells of the stomach

Source of HCl & Intrinsic Factor (req. for Vit B12 absorption)

function of chief cells of the stomach

Produces pepsinogen & lipase (enzymes)

function of Enteroendocrine cells of the stomach

Endocrine function (gastrin)

What is this gland?

(Stomach) Cardiac Glands

What is this gland?

(Stomach) Fundic Glands

What is this cell?

Surface Epithelial Cells

What is this gland?

(Stomach) Pyloric Glands

What are the two cells? (blue = ?) (pink = ?)

blue = surface mucous

pink = mucous neck

What is this cell?

Parietal Cells

What is this cell?

Chief Cells

What is this cell?

Enteroendocrine Cells

What does this cell produce?

Gastrin

What does this cell produce?

Pepsinogen & lipase

What does this cell produce?

HcL and intrinsic factor

What does this cell produce?

Mucus

Label the gland of the stomach

Pyloric Glands

Label the gland of the stomach

Cardiac Glands

Label the gland of the stomch

Fundic

What is the gland?

What cells are seen here?

Fundic gland

parietal cells in pink

Chief cells in pale

What are the cells here and what glad would they be seen in?

Enteroendocrine Cells (Black) of the Fundic Gland

• Short gastric pits, short glands

• Branched tubular glands in shape

What gland?

cardiac glands

Contain deep gastric pits

Primarily mucus producing

Some enteroendocrine cells are present

What gland?

Pyloric

• Short pit, long gland

• Account for 99% of all stomach glands

• Main acid (HCl) and enzymatic producing glands of the stomach

What gland?

Fundic

________ esphagus is when the esophagus is exposed to stomach contents and metaplasia of the epithelium occurs 

Barrett's

The stomach is composed of 4 layers and has 4 regions which include the ?

cardia, fundus, body, and pylorus

Which is the most common stomach gland?

Fundic

_______ cells typically stain pink, and are seen with the pale staining _____ cells

parietal; chief

What type of cells are these

(enteroendocrine cells) - these appear dark brown or black

Muscularis externa of the stomach contains 3 layers of smooth

muscle

• Outer ______

• Middle ______

• Inner _______

longitudinal

circular

oblique

Layers of the stomach

Gastric pits (epi) → gastric glands (LP) → MM → SM → musc mucosa → serosa

Label the two plexus

________: Protective, absorptive, or secretory stratified squamous/columnar epithelium that forms glands and may be thrown into folds or villi

Epithelium

_______: Contains glands, lymphatic tissue and macrophages

Lamina Propria

________: 2 thin layers of smooth muscle that promote movement of mucosa

Muscularis Mucosa

The ______ connects mucosa to muscularis externa and is formed of dense connective tissue. Contains submucosal/Meissner’s plexus and can also contain exocrine glands 

submucosa

The _________ consists of two substantial layers of smooth muscle- an inner layer of circularly arranged smooth muscle and outer layer of longitudinally arranged smooth muscle.

muscularis externa

The ______ is composed of loose connective tissue that is covered by a simple squamous mesothelium

The ______ is made up of connective tissue

serosa

adventitia

Gastric glands (cardiac, fundic, and pyloric), located in the lamina propria, form as invaginations of the ?

surface epithelium

in the stomach, the ________ located between between circular and longitudinal layers

Myenteric plexus

Where are esophageal cardiac glands located?

lamina proposa

where are esophageal glands (proper) located?

submucosa

What comes first meissers plexus or myenteric/aurebach?

meissers

meissers = lamina proposa

Myenteric = muscular externa

what is the distiction with the adventitia, serosa, and the palenteal cavity

The advintita ispast the muscular externa (last layer)

the esophagus has adventita, but the rest of the GI tract does not

The esophagus’ palanteal cavity is in the serosa, but the rest of it is in the adventita

the inner mucle of the muscular externa = ?

circular

the outer muscle of the muscula externa =

longitudinal

What are the 4 layers of the intestinal wall?

mucosa → submucosa → muscularis externa → serosa/adventita

what are the three layers of the mucosa?

epi/gastic folds → lamina propa/gastric pits → muscularis mucosa

in the submucosa, ______ glands can be here

exocrine

the muscularis externa is comprised of?

two layers of smooth muscle

________

• Contains coarse collagenous and elastic fibers

• Contain folds

• Contain glands

Submucosa

________ - Mucus glands in the lamina propria near the stomach

________ - Mucus glands scattered in the submucosa

Esophageal Cardiac Glands

Esophageal Glands

What is this?

Esophageal Stomach Junction

______ cells stain pink and have numerous mitochondria and cell membrane invaginations forming canaliculi

Parietal

What is this

Parietal Cells of the Fundic Gland

what is this?

Chief Cells of the Fundic Gland