Group 2: DNA Replication

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11 Terms

1
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Semiconservative replication

Each helix is half old and half new DNA

2
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Initiator proteins

Bind to origin, open small region on DNA, and recruit DNA Helicase

3
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Helicase

Unwinds DNA strands by breaking Hydrogen bonds between bases

4
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Primase

Synthesizes the RNA primer

5
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RNA Primer

Short sequence of RNA that provides the starting point for DNA synthesis (provides 3’ OH)

6
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DNA Polymerase

Catalyst for making the phosphodiester bond that adds bases to a 3’ OH end of nucleotide (extends RNA primer)

7
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Leading strand

continuous

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Lagging strand

Discontinuous

9
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DNA Ligase

Seals the nicks and connects Okazaki fragments

10
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Proofreading

DNA polymerase detects and corrects its mistakes.

11
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ATP

Source of energy