Antibody isotype things need to know

the different things need to know about the different antibody isotypes - slide 17 of lecture 1

what is the heavy chain component of IgG?

gamma (γ)

what is the heavy chain component of IgA?

alpha (α)

what is the heavy chain component of IgM?

micro (μ)

what is the heavy chain component of IgE?

epsilon (ε)

what is the heavy chain component of IgD?

delta (δ)

which is the only antibody to cross the placenta?

IgG

which antibodies activate complement pathway?

IgG and IgM

which two isotypes are present on mature naïve B cell membranes?

IgM and IgD

which isotypes DON’T bind to Fc receptors on phagocytes

IgE and IgD

which isotypes use a poly-Ig receptor for mucosal transport

IgA and IgM

which induces mast cell/basophil/eosinophil degranulation?

IgE primarily,

little bit of IgD