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Insulin operates by
Tyrosine kinase pathway
Insulin promotes
dephosphorylation of glycogen synthase, glycolysis
Glucagon and epinephrine operate by
G-protein coupled receptor
Glucagon and epinephrine promote
Phosphorylation glycogen breakdown and gluconeogenesis
After eating:
Insulin release from pancreas
Glucose high in blood, uptake into cells
Glycolysis starts
Gluconeogenesis stops
Glycogen breakdown stops in liver, kidney
Glycogen synthesis begins in liver, kidney and skeletal muscle
Fasting:
Glucagon release from pancreas
Glucose low in blood, uptake low in cells
Glycolysis stops
Gluconeogenesis starts in liver
Glycogen breakdown starts in liver, kidney
Glycogen synthesis stops