COVID 19, Tdap, Shingles, Hep B

how many types of covid 19 vaccines

2 types

mRNA

• lipid nanoparticles formulated, nucleoside-modified mRNA vaccines encoding the perfusion spike glycoprotein of SARS-CoV-2

• mRNA gets injected to cell —> body makes a spike protein

• body makes antigen while immune sys makes antibodies

• if mutated, can sequence new mrna acquired for mutation

mRNA brands

• cominarty

• spikevax

• mNEXSPIKE

protein-based

• contains pieces (protein) of virus (spike protein) causes covid

• contains an adjuvant

protein-based brands

NUVAXOVID

dose recommendation children/adolescents

• no CDC rec for 6-23 months & 2-18 years

dose recommendation children/adolescents

• 19-64: one or more doses

• 65 & older: 2 or more doses

recommednation for pt 65 and older, and those immcomp

• get 2 doses, 6 months apart

can covid-19 vaccines be administered w/ other vaccines

yessssssss

when covid vaccine first came out

• og did not recommendation to give with other vaccines at first

what disease has been eradicated

• smallpox

• could come back

• bc no one is vaccinated for smallpox

tetanus, diphtheria & pertussis vaccine

= Tdap

how many types of vaccines

2

DTaP (kids)

diphtheria- tetanus - pertussis

• toxoid vaccines combines w/ acellular bacterial vaccines, aluminum adjuvant

• higher Diphtheria & Pertussis conc

DTap brands

• Daptacel

• Infanrix

Tdap - adults

• toxoid vaccines combined w/ acellular bacterial vaccine, aluminum adjuvant

• 1/3 dose of diph & less dose of pert antigen

Tdap brands

• adacel

• Boostrix

recommendations of age

• 6 weeks to 6 years: one DTaP

• 7-10 years: one Tdap

• 11- 64 years: one Tdap

  • booster every 10 years for adults

do you get Tdap every pregnancy

yes, 27-36 weeks

• if not given in pregnancy, administer as soon as post-partrum

what is the recommended interval between a dose of Tdap and the last Td booster

• none, Td booster is not around much

zoster vaccine (herpes zoster)

zoster vs varicella

zoster: shingles

varicella: chickenpox

• same virus causes both disease

what happens when you get shingles

• A blistering, painful rash that follows a specific dermatome (an area of skin supplied by a single spinal nerve)

• can get into eyes, ears

• months to years to go away

• wearing clothes can hurt

zoster brand

shingrix

• recombinant

precuation of zoster vaccines

• pregnancy

vaccine recommendations

• origonal vaccine (Zosta Vax) was live, been off the market

• 2 doses series

• healthy 50 and older, include those got old live vaccine

• immunocomp adults 19 & older

does zoster vaccine have more side affects than typical vaccines

yes

shingle series

• 2 shot series

• repeats again in 2-6 months

• earliest for 2nd shingle shot is one month, if earlier is not a booster

• you don’t have to restart series if late for booster

Hepatitis B Vaccine

how many types of Hep B vaccines

2

recombinant aluminum adjuvant

• produced by inserting a plasmid containing gene for HBsAg into years

• aluminum adjuvant causes a strong immune response rxn, more efficacy

aluminum adjuvant brands

• Engerix -B

• Recombivax HB

recombinant synthetic adjuvant

• inserting a plasmid w/ gene for HBsAg into yeasr

synthetic adjuvant

• Heplisav -B

exception of Hep B vaccine

should get right at birth where as others would wait until 2 yrld

Hep B vaccines recommnedation - kids

• all infants

  • (3 doses series)

  • birth, 1-2, 6-18 months

• all adolscents who havent been vaccinated

Hep B vaccines recommnedation - adults

• 19-59 who havent s been vaccianted

• all 60 and older healthy or none healthy