CMS 2 - ALL antibodies

Acetylcholine receptor antibody

myasthenia gravis

Beta-2 glycoprotein 1 antibody

Antiphospholipid syndrome (APS)

lupus anticoagulant (LAC)

antiphospholipid syndrome (APS)

*most pathogenic!

anti-cardiolipin (ACL)

Antiphospholipid syndrome (APS)

IgG is the worst one!!

Anti-centromere

lcSS (CREST)

Anti-CCP

RA

anti-dsDNA

lupus nephritis

GBM antibodies

Goodpasture's (this is CMS3 but oh well)

Anti-histone

Drug-induced lupus

anti-Jo-1

Polymyositis, dermatomyositis

*assoc w ILD!!!!!!

anti-SSA (Ro) & anti-SSB (La)

Sjogren syndrome (SSA more pathogenic)

SCLE

neonatal lupus (SSA more pathogenic)

Lupus anticoagulant (LAC)

antiphospholipid syndrome

Mi-2

Dermatomyositis (specific to DM)

Anti-mitochondrial

primary biliary cirrhosis

P-ANCA

Microscopic polyangitis (MPA)

EGPA

PAN (not always there)

UC

primary sclerosing cholangitis (PSC)

anti-myeloperoxidase (MPO)

EGPA

c-ANCA

GPA

*more specifically anti-proteinase 3 abs

Rheumatoid factor

RA

anti-U1 RNP

Mixed connective tissue disease

ASCA

Crohn's

anti-SCL 70

dcSS

Anti-SRP

immune-mediated necrotizing myopathy (IMNM)

anti-HMG CoA reductase

statin induced myopathy

anti-RNA 3 polymerase

GAVE "watermelon stomach"

anti-CN1A

inclusion body myositis

Anti-smith

SLE (specific to SLE!!!)

ASMA (anti-smooth muscle ab)

Autoimmune hepatitis

Anti thyroglobulin (TG)

Hashimoto thyroiditis

Anti-TPO

Hashimoto's

Anti-transglutaminase (tTG)

Celiac

TR-Ab

graves (TSH receptor Ab)

voltage gated Ca channel antibodies

Lambert-Eaton syndrome

Anti-21-hydroxylase

addison's disease

antimitochondrial Ab (AMA)

primary biliary cholangitis (PBC)

Hep B & C

PAN

hep C = cryoglobulinemia

adrenal cortex antibodies (ACA)

addison's disease

islet cell Ab

T1DM -- these abs target glutamic acid decarboxylase (GAD) in pancreatic beta cells

anti-insulin antibodies

T1DM