Oxygen Dissociation Curve

Vocabulary flashcards covering the oxygen dissociation curve, differences between myoglobin and hemoglobin, and factors affecting T-state and R-state transitions.

Myoglobin ($Mb$) Binding Curve

A hyperbolic curve that reflects a single binding site and no cooperativity.

Hemoglobin ($Hb$) Binding Curve

A sigmoidal curve that reflects multiple binding sites and cooperativity.

What can cause a left shift?

pH increase, oxygen affinity increase

Decrease in CO2, H+, ionic bonds, and 2,3BPG

What state favors the left shift?

R state

What causes a right shift?

pH decrease, oxygen affinity decrease

Increase in CO2, increase in H+, increase in 2,3 BPG

What state does the right shift favor?

T state

P50

Pressure of oxygen in blood where hemoglobin is 50% saturated with oxygen.

P50 shifts?

Lower p50 = left shift

Higher p50 = right shift

Low $pO_2$ on Dissociation Chart

Represents the physiological conditions found in tissue.

High $pO_2$ on Dissociation Chart

Represents the physiological conditions found in the lungs.