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Layers of the integument (skin)
Epidermis
Dermis
Hypodermis (subcutaneous) layer
Structural and functional relationship of epidermis
Structure- the epidermis is a stratified squamous epithelium; made of epithelial cells
Function- a tough, waterproof protective barrier that shields internal body tissues from environmental damage, pathogens, and fluid loss
Simpler version: to act as a tough, waterproof outer barrier that protects the body from environmental harm
Structural and functional relationship of dermis
structure- dense connective tissue and fibrous proteins
Function- provide structural support, strength, and elasticity to the skin while housing vital structures that supply nutrients, sense the environment, and regulate body temperature
What are the layers of the epidermis (top to bottom)?
Stratum corneum
Stratum lucidum
Stratum granulosum
Stratum spinosum
Stratum basale
Mnemonic: Come, let’s get sun burned

How many thin layers of the epidermis are there, and what are they?
4 layers:
Stratum corneum
Stratum lucidum
Stratum granulosum
Stratum spinosum
How many thick layers of the epidermis are there, and what are they?
5 layers:
Stratum corneum
Stratum lucidum
Stratum granulosum
Stratum spinosum
Stratum basale
What are the layers of the dermis?
Papillary dermis (upper layer)
Reticular dermis (lower layer)
Papillary layer function (dermis)
Supply the outer layer of skin (epidermis) with nutrients and remove waste products
Reticular layer function (dermis)
provides structural strength, elasticity, and support to the skin
How is skin color determined?
by the amount, type, and distribution of a pigment called melanin in your skin cells, which is controlled by multiple genes working together
Skin color (melanin, carotene, hemoglobin)
melanin- makes skin darker
Carotene- makes your skin yellow or orange
Hemoglobin- gives skin pink, red, or blue-red tones
Eccrine sweat gland (dermis)
secrete clear, watery sweat that evaporates from your skin to cool your body down
Arrector pili muscle location and function
Location- dermis
Function- involuntarily contract and pull hair follicles upright
Sebaceous (oil) gland (dermis)
produce and secrete sebum, an oily mixture of lipids that lubricates and protects the skin and hair
Hair follicle (dermis)
grow your hair
Hair root (dermis)
anchor the hair strand within the skin and actively produce new hair through rapid cellular division
Dermal vascular plexus (dermis)
Regulate body temperature and supply nutrients to the skin
Sensory nerve fiber with free nerve endings (dermis)
unencapsulated receptors that detect pain, temperature, itch, and crude touch
Lamellar corpuscle (dermis)
detect deep pressure, stretch, and high-frequency vibrations
Hair follicle receptor (dermis)
detects light touch and hair movement
Where is thin skin found?
almost everywhere
Where is thick skin found?
On the palm of hands and soles of feet
How does hair growth work?
happens inside tiny pockets in the skin called hair follicles, where fast-multiplying cells create a hard protein called keratin that pushes upward to form the visible hair strand
How does baldness occur?
where hair follicles shrink over time and stop producing new hair
What is the difference between eccrine and apocrine sweat glands?
eccrine-
Found everywhere on the body
Goes through pores
Cools the body down; odorless
Apocrine
Found on the armpits, groin, and scalp
Goes into hair follicles
Reacts to emotional stress and hormonal changes; creates body odor when broken down by skin bacteria
What are the sensory receptors?
free nerve endings
Pacinian corpuscles (lamellar corpuscles)
Hair follicle receptor
Meissner’s corpuscle
Pacinian corpuscles location and function
location- deep in the skin and internal tissues
Function- detect high-frequency vibrations and deep pressure
Hair follicle receptor location and function
location- surrounds hair follicle which is superficial to the hair
Function- act as a sensitive touch receptor
Meissner’s corpuscle location and function
location- superficial layers of the skin
Function- detect light touch and low-frequency vibrations
Free nerve endings location and function
location- throughout the body
Function- detect pain, temperature, and crude touch
What are the cells of the epidermis?
keratinocytes
Melanocytes
Dendritic cell
Merkel cell
keratinocytes
main cells in the outer layer of your skin
Produce a protein called keratin (fibrous protein found in epidermis, hair, and nails that makes those structures hard and water resistant)
Contain melanin, but don’t make their own melanin
melanocytes structure and function
produce a pigment called melanin (brown pigment)
Structure- have projections/processes which fill in the gap between keratinocytes
Melanin travels through the projections and is transferred into the keratinocytes
*fun fact: in response to UV radiation, melanin orients itself
Dendritic cell
Protective cells that engulf antigens, migrate to lymph nodes, and present the antigen to T cells, causing them to activate and mount an immune response
phagocytic
Merkel cell
Specialized touch receptors that detect light touch, tactile touch, and pressure
What is the dermis made of?
connective tissue
What are the functions of the skin?
Protection
Excretion
Temperature regulation
Sensation
Blood reservoir
Excretion
protection (skin)
Physical protection- layers
Chemical protection- keratin and produces antibacterial substances
Biological protection- cells for the immune system called dendritic cells
excretion (skin)
Urea and salt
Temperature regulation (skin)
Sweat glands- evaporative cooling
Arrector pili muscles
Blood vessel diameter
Sensation
form nervous system receptors
Blood reservoir (skin)
5% of your blood is stored in the skin
metabolic functions
produced vitamin D
What are the three types of burns?
First-degree burns
Second-degree burns
Third-degree burns
First-degree burn characteristics, layer affected, and healing time
characteristics- localized redness, swelling, and pain
Layer affected- only epidermis
Healing time- two to three days
Second-degree burn characteristics, layer affected, and healing time
characteristics- similar to first-degree burns, but blisters also appear; red and painful
Layer affected- injure the epidermis and the upper region of the dermis
Healing time- three to four weeks
Third-degree burn characteristics, layer affected, and healing time
characteristics- burned area appears gray-white, cherry red, or blackened; no swelling
Layer affected- all layers of skin
Healing time- several weeks to several years
Is the hypodermis part of the skin?
NO
What is the function of the hypodermis?
providing insulation, energy storage, and shock absorption