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primary resources
original research studies & reports
-use to example study methods and results
-ex. clinical trials, cohort studies
strengths of primary sources
detailed data from the original study
limitations of primary sources
requires literature evaluation skills
secondary resources
searchable index of published literature
-use to find articles on a topic
-ex. PubMed
strengths of secondary sources
search across many publications
limitations of secondary sources
search & access can be challenging
tertiary resources
summaries of multiple sources
-use to answer routine drug questions
-ex. UpToDate, Micromedex
strengths of tertiary sources
quick reference summaries
limitations of tertiary sources
may be incomplete or reflect author bias
Pediatric & Neonatal Handbook
gold standard for pediatric dosing
-in UpToDate
Drugs in Pregnancy & Lactation (“Briggs”)
gold standard for evaluating risk potential to fetuses & infants during pregnancy & lactation
-original studies cited within monograph
-in UpToDate
Micromedex
has IV compatability
Handbook of Injectable Drugs (“Trissel’s”)
gold standard for IV stability & compatibility
-in Micromedex
red book
pricing information
orange book (FDA)
list of approved generic therapeutic equivalent drugs
yellow book (CDC)
all required vaccines needed for travel
-includes prophylactic meds
green book (FDA)
info on FDA approved animal drugs on safety and effectiveness
purple book (FDA)
info on biological drug products & interchangeable products
pink book (CDC)
info on vaccine-preventable diseases and disease epidemiology
UpToDate
-tertiary
-best for clinical questions, dosing, interactions
Natural Medicines
-tertiary
-best for supplements and herbal interactions
Rainbow Books/FDA Shortages
-tertiary
-best for specialized topics (pricing, equivalence, travel, shortages)
PubMed
-secondary
-best for finding published studies on a topic
journal articles, clinical trials
-primary
-best for evaluating the evidence directly, citing the original source