the effects of inflammatory mediators

inflammatory mediators

chemical signals promoting or inhibiting inflammation

histamine (naturally produced by body)

causes vasodilation increasing vascular permeability allowing more blood and fluid to enter the tissue causing redness, warmth and swelling

bradykinin (naturally produced by body)

causes vasodilation increase blood flow to injured areas increasing swelling and pain

prostaglandins

contribute to pain, inflammation and fever working with hypothalamus to raise body temp

leukotrienes

increase inflammation and activation of WBC’s

TNF alpha and interleukins

cytokines that activate and coordinate the inflammatory response and help recruit immune cells —> chemical messengers made by body

interleukins can turn inflammatory

up or down