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Infection Prevention
Methods practiced in healthcare facilities to prevent and control the spread of disease.
Microorganism (Microbe)
A living organism so small that it can only be seen with a microscope.
Pathogens
Harmful microorganisms that invade the body and cause infection or disease.
Localized Infection
An infection limited to a specific area of the body, causing symptoms near the site.
Systemic Infection
An infection that enters the bloodstream and affects the entire body.
Healthcare-Associated Infection (HAI)
An infection acquired in a healthcare facility while receiving medical care.
Signs of Localized Infection
Pain, redness, swelling, pus, fluid drainage, and heat at the site.
Signs of Systemic Infection
Fever, chills, body aches, nausea, vomiting, weakness, headache, confusion, low blood pressure, or rapid breathing.
Chain of Infection
A six-link model describing how disease spreads from one host to another.

Causative Agent and which chain link
The disease-causing pathogen, such as bacteria, viruses, fungi, or parasites (Chain Link 1).
Normal Flora
Microorganisms that live harmlessly in/on the body unless transferred to a different body part.
Reservoir and which chain link
The warm, dark, moist environment where a pathogen lives and multiplies (Chain Link 2).
Portal of Exit and which chain link
Any body opening that allows pathogens to leave an infected person, like the mouth, nose, or open wounds (Chain Link 3).
Mode of Transmission and which chain link
How a pathogen travels from host to host via contact, droplets, or air (Chain Link 4).
Direct Contact Transmission
Spread of germs by physically touching an infected person or their secretions.
Indirect Contact Transmission
Spread of germs by touching a contaminated object, like linens, tissues, or needles.
Standard Precautions
Infection control rules treating all blood, body fluids, non-intact skin, and mucous membranes as infected for every patient.
Body Fluids
Fluids like blood, saliva, urine, feces, vomit, pus, and semen (excludes sweat).
Transmission-Based Precautions
Extra infection controls added to Standard Precautions based on how a specific disease spreads.
Sharps
Sharp medical objects like needles and razor blades that must be placed in puncture-resistant biohazard containers.
Multidrug-Resistant Organisms (MDROs)
Bacteria resistant to one or more antibiotics commonly used for treatment, like MRSA and VRE.
Airborne Precautions
Controls for airborne germs that float long distances; requires an N95 mask and negative-pressure room.
Droplet Precautions
Controls for germs spread through large droplets traveling up to 6 feet; requires a face mask.
Contact Precautions
Controls for germs spread by direct/indirect touch; requires gloves, gown, isolated room, and dedicated equipment.
Isolate
To keep a patient or object separate from others to prevent infection spread.
Respiratory Hygiene / Cough Etiquette
Infection rules to stop respiratory germs, including covering coughs, disposing tissues, and wearing masks.
Epidemic
A disease outbreak affecting a large number of people in a specific geographic area.
Pandemic
A global disease outbreak that spreads across multiple countries or continents.
Endemic
A disease that is constantly present in a specific region or population at expected levels.
Contact Time
The required amount of time a disinfectant must remain wet on a surface to kill pathogens.
Sterilization
A cleaning process using intense heat or chemicals to destroy all microorganisms, including spores.
Autoclave
A high-pressure steam machine used to sterilize medical instruments.
Handling Soiled Linen
Fold dirty areas inward, keep away from uniform, do not shake, and bag immediately at point of origin.
CRE (Carbapenem-Resistant Enterobacteriaceae)
Antibiotic-resistant intestinal bacteria that can cause severe, life-threatening infections.
Clostridioides difficile (C. diff)
Spore-forming gut bacteria causing severe diarrhea; resistant to alcohol sanitizer and requires soap and water.
OSHA (Occupational Safety and Health Administration)
A federal agency that creates regulations to protect workers from job hazards, including infections.
CDC (Centers for Disease Control and Prevention)
A federal health agency that provides disease prevention guidelines for healthcare workers.