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Biotin structure
Ureido ring fused with a tetrahydrothiophene ring + valeric acid side chain
Biotin Active Form
Biocytin (bound to
carboxylases)
Biotin RDA and UL
Men and Women: 30mcg/day
Pregnancy/Lactation: 30-35 mcg/day
UL: none established
Biotin Rich Food Sources
Eggs (cooked), liver, nuts, seeds, sweet potatoes, salmon
Biotin Metabolic Functions
Carboxylation reactions in gluconeogenesis (pyruvate carboxylase) and fatty acid synthesis (acetyl-CoA carboxylase).
Biotin Insufficiency Effects
halts glucose generation
Biotin Deficiency Symptoms
Hair thinning/loss, scaly red rash around eyes/mouth/nose, depression, lethargy, hallucinations
Biotin Deficiency at risk population
Raw egg white consumers (avidin binding), biotinidase deficiency, pregnant women.