Glutathione S-Transferase

Glutathione S-Transferase

EC 2.5.1.18; GST

Cytosolic glutathione S-transferases are dimeric enzymes that catalyze the________________ to the electrophilic centers of a wide variety of chemical structures, accomplishing __________.

nucleophilic addition of glutathione

detoxification reactions

The family of human enzymes is divided into four main classes:

α, µ, π, θ

Alpha-GST is found at high concentrations in the ___________ and is released quickly and in large quantities from ___________ into the ______________.

human liver

damaged hepatocytes

bloodstream

Alpha-GST is an emerging marker for assessing ____________.

hepatocellular damage

Unlike aminotransferases, which are found predominantly in the _____________ a-GST is evenly distributed across the ____________ and is therefore released in all types of _______________.

periportal hepatocytes

liver acinus

hepatocyte injury

In liver transplant recipients, __________ was found more valuable than AST in detecting early rejection episodes postoperatively and less susceptible to the confounding effects of infection.

a-GST

Using a commercially available enzyme immunoassay for a-GST, the upper reference limit was __________.

11.4ug/L