The Immune System

Flashcards about the immune system

LYMPHOID ORGANS

Red bone marrow, thymus, lymph nodes, spleen, SALT, MALT, GALT, BALT, skin, mucosa, gut, breast- associated lymphatic tissue and A loose connective tissue framework that houses aggregations of lymphocytes primary lymphatic organs

Markers – Antigens

proteins, glycoproteins, lipoproteins found on all cells and microbes that can be recognized by the immune system as self or non-self

PAMPs – pathogen-associated molecular patterns

antigens that many microbes have in common

PPRs – patten recognition receptors

Host cell receptors that recognize PAMPs

MPS – Mononuclear phagocyte system

phagocytes throughout connective tissues that surround organs

Pathogen-associated molecular patterns (PAMPs)

Recognized by phagocytes and other defensive cells and Serve as signal molecules on the surfaces of microbes, Not present in mammals

Pattern recognition receptors (PRRs)

Found on the surfaces of phagocytes, dendritic cells, endothelial cells, and lymphocytes that Recognize and bind PAMPs and are Found on the surface at all times, regardless of whether they have encountered a PAMP

Toll-like receptors (TLRs)

a type of PRR that recognizes PAMPs and orchestrates a defense response to the pathogen

Collectins

exogenous proteins not part of cell membrane that roam blood & tissues

Epitope

portion of the antigen molecule recognized and responded to by a lymphocyte

Haptens

Too small by themselves to elicit an immune response but if linked to a carrier group, the combined molecule develops immunogenicity

Alloantigens

Proteins and other molecules of one person that are antigenic to another and Cell surface markers that occur in some members of the same species but not in others

Superantigens

Bacterial exotoxins that are potent stimuli for T cells Activate T cells at a rate 100 times greater than ordinary antigens

Antigen-presenting cells (APCs)

Macrophages, B cells, Dendritic cells