Pharmacology: PDE5 Inhibitors and Alpha-1 Blockers for ED and BPH

Sildenafil: brand name

Viagra

Viagra: generic name

Sildenafil

Sildenafil: drug class

PDE5 inhibitor

Sildenafil: main use

Erectile dysfunction and pulmonary hypertension

Sildenafil: top 3 ADRs

Headache, Flushing, Blue-tinted vision

Sildenafil: How long to hold nitroglycerin after a dose

24 hours (never combine with nitrates)

Sildenafil: Erection lasting more than 4 hours

Priapism, a medical emergency

Tadalafil: brand name

Cialis

Cialis: generic name

Tadalafil

Tadalafil: drug class

PDE5 inhibitor

Tadalafil: main use

Erectile dysfunction, BPH and pulmonary hypertension

Tadalafil: top 3 ADRs

Headache, Back pain / myalgia, Flushing

Tadalafil: Duration of action

36 hours

Tadalafil: How long to hold nitrates after a dose

48 hours

Tadalafil: Which PDE5 inhibitor also treats BPH

Tadalafil

Vardenafil: brand name

Levitra

Levitra: generic name

Vardenafil

Vardenafil: drug class

PDE5 inhibitor

Vardenafil: main use

Erectile dysfunction

Vardenafil: top 3 ADRs

Headache, Flushing, Nasal congestion

Vardenafil: How long to hold nitrates after a dose

24 hours

Vardenafil: Unique cardiac risk

QT prolongation

Alprostadil: brand name

Caverject (injection) / Muse (urethral)

Caverject: generic name

Alprostadil

Muse: generic name

Alprostadil

Alprostadil: drug class

Prostaglandin E1 analog

Alprostadil: main use

Erectile dysfunction when PDE5 inhibitors fail

Alprostadil: top 3 ADRs

Penile pain, Priapism, Penile fibrosis

Alprostadil: Why it works after spinal cord injury

Works without nerves or nitric oxide

Doxazosin: brand name

Cardura

Cardura: generic name

Doxazosin

Doxazosin: drug class

Nonselective alpha-1 blocker

Doxazosin: main use

BPH and hypertension

Doxazosin: top 3 ADRs

First-dose orthostatic hypotension / syncope, Dizziness, Fatigue

Doxazosin: When to give the first dose

At bedtime (first-dose orthostasis)

Prazosin: brand name

Minipress

Minipress: generic name

Prazosin

Prazosin: drug class

Nonselective alpha-1 blocker

Prazosin: main use

BPH, hypertension and PTSD nightmares

Prazosin: top 3 ADRs

First-dose syncope, Dizziness, Nasal congestion

Prazosin: Unique extra use

PTSD nightmares

Terazosin: brand name

Hytrin

Hytrin: generic name

Terazosin

Terazosin: drug class

Nonselective alpha-1 blocker

Terazosin: main use

BPH and hypertension

Terazosin: top 3 ADRs

First-dose orthostasis, Dizziness, Fatigue

Terazosin: When to dose

At night (first-dose orthostasis)

Alfuzosin: brand name

Uroxatral

Uroxatral: generic name

Alfuzosin

Alfuzosin: drug class

Selective alpha-1 blocker

Alfuzosin: main use

BPH only

Alfuzosin: top 3 ADRs

Dizziness, Retrograde ejaculation, Headache

Alfuzosin: Does it treat hypertension

No, selective alpha-1 blockers treat BPH only

Tamsulosin: brand name

Flomax

Flomax: generic name

Tamsulosin

Tamsulosin: drug class

Selective alpha-1 blocker

Tamsulosin: main use

BPH only

Tamsulosin: top 3 ADRs

Retrograde ejaculation, Dizziness, Floppy iris syndrome

Tamsulosin: Who to warn before starting

The eye surgeon before cataract surgery (floppy iris syndrome)

Tamsulosin: Does it treat hypertension

No, BPH only

Finasteride: brand name

Proscar (BPH) / Propecia (hair)

Proscar: generic name

Finasteride

Propecia: generic name

Finasteride

Finasteride: drug class

5-alpha reductase inhibitor

Finasteride: main use

BPH and male pattern baldness

Finasteride: top 3 ADRs

Decreased libido / ED, Ejaculatory dysfunction, Gynecomastia

Finasteride: Effect on PSA

Halves it, so double the measured PSA

Finasteride: Who must not handle the tablets

Pregnant women (teratogen)

Dutasteride: brand name

Avodart

Avodart: generic name

Dutasteride

Dutasteride: drug class

5-alpha reductase inhibitor

Dutasteride: main use

BPH

Dutasteride: top 3 ADRs

Decreased libido / ED, Ejaculatory dysfunction, Gynecomastia

Dutasteride: Time to work

3-6 months

Dutasteride: Effect on PSA

Halves it, so double the measured PSA

Testosterone: brand name

AndroGel / Depo-Testosterone

AndroGel: generic name

Testosterone

Depo-Testosterone: generic name

Testosterone

Testosterone: drug class

Androgen (Schedule III)

Testosterone: main use

Hypogonadism and delayed male puberty

Testosterone: top 3 ADRs

Increased hematocrit (polycythemia), Acne, Gynecomastia / edema

Testosterone: Lab that means stop the drug

A significant rise in hematocrit

Testosterone: Gel risk to family

Transfers to women and children by skin contact

Testosterone: DEA schedule

C-III

Minoxidil (topical): brand name

Rogaine

Rogaine: generic name

Minoxidil (topical)

Minoxidil (topical): drug class

Vasodilator

Minoxidil (topical): main use

Male pattern baldness

Minoxidil (topical): top 3 ADRs

Scalp irritation, Unwanted facial hair, Hair shedding at start

Minoxidil (topical): Where it works best

The crown (vertex)

Minoxidil (topical): What happens if stopped

Hair loss returns

Ceftriaxone: brand name

Rocephin

Rocephin: generic name

Ceftriaxone

Ceftriaxone: drug class

3rd-generation cephalosporin

Ceftriaxone: main use

Epididymitis from an STD (with doxycycline)

Ceftriaxone: top 3 ADRs

Diarrhea, Rash, Injection-site pain

Ceftriaxone: Paired with for STD epididymitis

Doxycycline (covers gonorrhea + chlamydia)

Doxycycline: drug class

Tetracycline antibiotic

Doxycycline: main use

Epididymitis from an STD (with ceftriaxone)

Doxycycline: top 3 ADRs

Photosensitivity, GI upset / esophagitis, Tooth discoloration in kids and pregnancy