people for MBI 111

Robert Hooke

• he made the microscope well known, also coined the name the cell

Zacharias Jameson

was the person who created the first microscope

Schelidion and Schawann

• Later proposed that cells are the fundamentals of life

Antonie van Leeuwenhoek

 He was a man of very much importance and he was just very interested in microscopes and so in his spare time he built microscopes and he was then able to describe the movement of various bacterias in the shapes that they make. Also sent letters to the Royal Society of London

Girolamo Fracosoro

• Proposed the idea of invisible particles causing disease- he was pretty much spot on about how diseases is transmitted. 

Athanasius Kircher

• Observed what he thought were microscopic worms in the blood of plague victims- but he was incorrectly believe that they caused the plague 

Aristotle

• He was a big believer  of spontaneous generation

Franceso Redi

• The reason that flies had people protective organs coming laid eggs on meat,  kind of Debunked spontaneous generation

John Needham

• He performed an experiment where he heated broth  to kill  microorganisms to the containers but then the outcome of that experiment still had organized present so he kind of believed in spontaneous regeneration 

Lazzaro Spallanzani

Boiled meat and vegetables and broth for a long time and sealed the flask by melting the glass necks( he corrected Needham's experiment ) And no organisms were present.

Louis Pasteur

•  He settled the controversy between Needham and Spallanzani. Key influenced a lot of things in those included fermentation,  pasteurization,  and then he also created the vaccine for rabies, anthrax ( was also very interested in this) and Chicken cholera

Joseph Lister:

Really liked Pastures germ theory , He began applying antiseptics to wound infections

Robert Koch

• He discovered that specific organisms caused specific diseases. He came up with a list in order to relate certain microorganisms to a disease 

• Also developed the pure culture technique

• - Must always be present in the disease 

                 -Isolate and grow the disease 

                 -Reproduce the disease

- recover the same microorganism in a disease animal

Edward Jenner

Help develop the first of vaccination for smallpox - from cowpox

Lady Mary Wortley Montagu

Promoted and variation against smallpox 

John Snow

He was the father of epidemiology - He  mapped the outbreak of of Cholera

Chadwick

developed a basis for the greatest sanitary movement and proposing network of sewer systems

Ignaz Semmelwies

He believed in hand washing

Alexander Fleming

he accidentally discovered a (bread) mold that kills strep colitis and became later known as penicillin, at first people did not really believe him - he was a doctor not a scientist

Gerhard Domgak

• Discovered prontosil,  an antibacterial drug used to treat certain types of bacterial infections, was a Nobel prize winner

Chain and Florey

• took flemings discovery one step further and created a practical antibiotic that could be used to treat serious bacterial infections, learned how to purify penicillin

• also noble peace prize winners

Jacques and Therese Trefoule:

discovered  that the liver is involved in metabolizing prontosil and when it is broken down it In a substance called sulfanilamide. - explained how prontosil worked.

Enders, Weller and Robbins:

developed tissue culture medium for growing poilo virus in host cells.

Salk:

• used formaldehyde to a polio Virus to inactivate it and then injected it into patients to help create a vaccine

Sabin

• Used an attendant  or weekend polio virus to create vaccine, was taken orally 

Franny Hasse

Assied her husband ( who worked with Koch) and suggested that they use agar instead of gelatin for the pure culture technique.

Von Behring and Kitasato

Discovered humoral immunity to diphtheria or tetanus was due to antibodies

Mechnikov

proposed the phagocytic theory of immunity - host cells ingest and destroy microbes

Paul Ehrlich

He saw antibodies as “magic bullets” made by the body and he wanted to develop the “ magic Bullets”

His ideas was that something could target a a specific disease causing agent.

#606 - he synthesized salvarsan, this was effective against syphilis