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Define Senescence
Biological aging and gradual decline in fucntion
Why are longer lived organisms often larger than shorter lived organisms?
Longer lived organisms have less predation, so they are able to focus their energy on growing larger and reproduce later in life. Short lived organisms are smaller because they focus the majority of their energy on survival due to more predation and as a result also produce sooner
Why do Bats live longer than Mice even though they are both small species?
Bats liver longer because flight allows them to escape predators
Why do mice frequently develop cancer?
Their lifespans are really short so there is little evolutionary benefit from investing in cancer prevention mechanisms
Which animals rarely develop cancer despite having large number of cells and long lifespans?
Elephants, whales, and tortoises
Why do elephants, whales, and tortioses rarely develop cancer?
Long-lived species gained a strong fitness advantage from preventing cancer that allows them to live a long lifespan and reproduce more successfully. Natural selection favored genes that improve DNA repair and cancer suppression.
When would delayed senescence be favored?
Favored when survival rates are high
Why does aging occur?
Aging occurs partly because repair mechanisms decline over time, not because repair mechanisms are absent
What are advantages to semelparity?
-Can reproduce many offspring at once
-If environmental conditions are ideal, many offspring may survive
What are disadvantages of semelparity?
-high energy investment in a single reproductive event
-no future reproductive opportunities
-high risk if environmental conditions are poor
What is the equation for phenotypic variation?
Vp = Vg + Ve
How does height exhibit additive genetic variation?
Many genes contribute small effects that combine additively to determine an individual’s height
Define Additive Genetic Variation
It is when the effects of multiple alleles simply add together to influence a trait
-Ex: 0 tall alleles —> shortest, 2 tall alleles —> slightly taller, together
Define polygenic trait?
Polygenic traits are traits influenced by multiple genes whose effects combine to produce a range of phenotypes
Is the color of hydrangeas determined by genetics or environment?
Environment because it is based on the acidity of the soil
How can the phenotype change without the DNA sequence changing?
The expression of the gene differs, that is the gene is either turned on or off. DNA needed for the gene expression is there, just not active/expressed
Define epigenetics
Changes in gene expression that occur without changing the DNA sequence; often caused by chemical tags attached to DNA
-methyl tags; can turn genes off and later be removed to restore gene activity
What can influence epigenetic marks?
-Environmental factors such as diet, stress, toxins can change how genes are expressed without changing the DNA sequence itself
Describe the Agouti gene in mice?
-Agouti gene on increases risks of obesity, type 2 diabetes, and cancer; yellow mouse
-Agouti gene off through methylation results in a healthier phenotype; brown mouse
-this is an example of epigenetics
What are environmental effects on trait for flamingos and beetles?
-Flamingos are naturally white, however due to their diet, they eat a lot of carotenoids that makes them appear pink
-Beetles that live in areas of high nutrition develop horns and areas of low nutrients, horns are absent or really small
In heritable variation what does h² represent?
represents the proportion of the variation in a trait within a population that is due to genetic differences among individuals.
What can be used to determine the heritable of a trait?
Offspring-parent regressions
H² ≈ 1.0 → represents?
trait was passed to offspring from parents; trait was strongly genetic
H² ≈ 0.0 → represents?
trait was strongly determined by environmental factors
How do you interpret heritability via H2 = 0.72
-72% of variation is due to genetic differences
-28% of variation is due to environmental differences
Define evolution
change in allele frequencies in a population over time; the smallest unit is the population
Define gene pool
All the alleles present in population
Define polymorphic and fixed locus
-multiple alleles present
-only one allele present
Genotype Frequency Formula is?
Genotype Frequency = Number with phenotype / total number of the population
What are the formulas for the dominant and recessive allele frequencies?
Dominant: p = f(A) = 2nAA + nAa / 2N
Recessive q = f(a) = 2naa + nAa / 2N
p + q = 1
Random mating will produce genotypes of the next generation in these proportions
f(A) = p
f(a) = q
f(AA) = p2
f(aa) = q2
f(Aa) = 2pq
What metrics can we use to describe a populations gene pool?
allele frequencies
genotype frequencies
genetic variation; amount of genetic differences
heterozygosity
heritability