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Nonpolar side chain
hydrophobic effect, buries the nonpolar sides together inside protein
Positive side chain
Ionic interactions/salt bridges with negatively charged groups
Negative side chain
Ionic interactions/salt bridges with positively charged groups
Polar, uncharged side chain
H-bonding with water/polar groups
Long side chain
It can reach farther, may enable interactions across larger distances
Bulky side chain
Can affect packing and create steric constraints
Small side chain
Can allow tighter turns, allow closer packing and flexibility
Aromatic side chains
Hydrophobic effect, can contribute to packing or ligand binding
Proline’s ring
Restricted backbone, introduce bends or disrupt helices