PFK-1 and PFK-2 in liver

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5 Terms

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what does PFK-1 do?

PFK-1 phosphorylates Fructose-6-phosphate → Fructose-1,6-bisphosphate (F-1,6-bP)

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what does PFK-2 do?

PFK-2 phosphorylates Fructose-6-phosphate → Fructose-2,6-bisphosphate (F-2,6-bP)

PFK-2 dephosphorylates Fructose-2,6-bisphosphate → Fructose-6-phosphate (F-6-P)

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effect of F-2,6-bP

Fructose-2,6-bisphosphate (F-2,6-bP) activates PFK-1.

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special characteristics of PFK-2

bi-functional enzyme with kinase and phosphatase activity

  • kinase activity:

    • activated by Pi

    • inhibited by citrate

  • phosphatase activity: inhibited by Fructose-6-phosphate


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REGULATION OF PFK-2 BY PHOSPHORYLATION

phosphorylated PFK-2:

  • PFK-2 phosphorylated by PKA

  • phosphatase activity stimulated

  • kinase activity inhibited

UNphosphorylated PFK-2:

  • PFK-2 is dephosphorylated by PP1; PP1 activated by Fructose-6-phosphate

  • phosphatase activity inhibited

  • kinase activity stimulated