management of androgen deficiency

primary androgenic deficiency is associated with what levels

high LH and low testosterone. neg feedback mech is trying to produce more testosterone by increasing levels of LH

which organ causes secondary androgen deficiency

hypothalamus and pituitary gland

secondary androgen def is associated with

low LH and low testosterone

where is primary androgen deficiency

dysfunction of the testes

where is secondary androgen deficiency

hypothalamus/ pituitary gland

highest levels of testosterone are at what age

20-30

what is so special about obesity being a cause of androgen deficiency

adipose tissue converts testosterone to estrogen. estrogen has negative feedback in hypothalamus = decreased testosterone levels

name some signs and symptoms of androgen deficiency

reduced libido, hot flushes/sweats, reduced facial hair growth, small testes, gynaecomaestia, osteoporosis

food intake can reduce testosterone levels by___%

25

is 1 low level of testosterone good enough to confirm a diagnosis

no- need at least 2

can we always use testosterone replacement therapy in older people

no- risk benefit ration is unclear

what are the forms of STARTING testosterone therapy

gel, cream, SA IM inj

what are the forms of MAINTAINING testosterone therapy

gel, cream, LA IM inj. as they give a more consistent dose response curve

how often should someones BMD get checked if on testosterone

every 1-2yrs

androgenic alopecia is associated with high levels of

dihydrotestosterone (DHT)

what are the treatment options for androgenic alopecia

no treatment, wigs, topical minoxidil 2-5%, finasteride/dutasteride (not licensed, but more effective), surgery