Elder

Abacavir

HLA-B57:01 hypersensitivity syndrome

Allopurinol

HLA-B*58:01 SJS/TEN and DRESS

Carbamazepine

HLA-B*15:02, HLA-B*31:01 SJS/TEN maculopapular exanthema

Phenytoin

HLA-B*15:02 SJS/TEN

SJS/TEN onset time

1-4 weeks

SJS/TEN presentation

Skin peeling and blistering

SJS/TEN systemic involvment

Fluid loss, infection, organ complications

DRESS onset time

2-8weeks

DRESS Presentation

rash, facial edma, fever

DRESS systemic involvment

internal organ injury(liver)

Hypersenistivity

an inappropriate immune response to a medication

Class 1 allels

HLA-A, HLA-B and HLA-C

Class 1 location

nearly all nucleated cells, inside the cell to CD8+ Tcells

Class 2 location

anti-gen presenting cells, outised the cell to CD4+ Tcells

Abacavir use

treat HIV, NRTI

Allopurinol use

lower uric acid

Carbamazepine use

treat seziures

Carbamazipine if allale positve

weigh risks

Phenytoin use

treat seizsures