Phosphoinositide Pathway (PI3K/Akt Pathway)

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Last updated 8:41 PM on 11/5/25
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5 Terms

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What does PI3K stand for?

Phosphoinositide 3-kinase.

2
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How is PI3K activated?

RTKs activate PI3K, which phosphorylates PIP2 to form PIP3.

3
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What does PIP3 do?

It recruits Akt (also called protein kinase B) to the membrane, where Akt becomes activated.

4
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What does activated Akt do?

Akt promotes cell survival and growth by inhibiting apoptosis and stimulating protein synthesis.

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What role does mTOR play in this pathway?

Akt activates mTOR, a key regulator of cell metabolism and growth.